CAMK2D and FNDC3B

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		CAMK2D	FNDC3B
Description		calcium/calmodulin dependent protein kinase II delta	fibronectin type III domain containing 3B
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Membrane Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Sarcolemma Neuron Projection	Integral Component Of Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Calmodulin-dependent Protein Kinase Activity Protein Binding Calmodulin Binding ATP Binding Sodium Channel Inhibitor Activity Titin Binding Identical Protein Binding Protein Homodimerization Activity Transmembrane Transporter Binding Protein Serine Kinase Activity	RNA Binding
	Biological Process	Regulation Of Cell Growth Regulation Of The Force Of Heart Contraction Regulation Of Membrane Depolarization Regulation Of Transcription By RNA Polymerase II Protein Phosphorylation Regulation Of Heart Contraction Positive Regulation Of Cardiac Muscle Hypertrophy Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cardiac Muscle Cell Apoptotic Process Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Endoplasmic Reticulum Calcium Ion Homeostasis Protein Autophosphorylation Relaxation Of Cardiac Muscle Regulation Of Ryanodine-sensitive Calcium-release Channel Activity Regulation Of Cellular Localization Cellular Response To Calcium Ion Cardiac Muscle Cell Contraction Regulation Of Heart Rate By Cardiac Conduction Regulation Of Cardiac Muscle Cell Action Potential Regulation Of Cardiac Muscle Cell Action Potential Involved In Regulation Of Contraction Regulation Of Histone Deacetylase Activity Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Regulation Of Relaxation Of Cardiac Muscle Negative Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Negative Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants
Drugs		2-[4-[4-[(5-cyclopropyl-1H-pyrazol-3-yl)amino]quinazolin-2-yl]iminocyclohexa-2,5-dien-1-yl]acetonitrile (3Z)-N,N-DIMETHYL-2-OXO-3-(4,5,6,7-TETRAHYDRO-1H-INDOL-2-YLMETHYLIDENE)-2,3-DIHYDRO-1H-INDOLE-5-SULFONAMIDE Fostamatinib
Diseases
GWAS		Atrial fibrillation ( 30061737 29892015) Chronic lymphocytic leukemia ( 28165464 24292274) Chronotype ( 30696823) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Hip circumference adjusted for BMI ( 28552196) Ischemic stroke (small-vessel) ( 29531354) Non-small cell lung cancer (survival) ( 25145502) P wave duration ( 28794112) Parkinson's disease ( 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) PR interval ( 30046033 32439900) Small vessel stroke (CCS and TOAST classification) ( 32047268) T wave morphology restitution during recovery from exercise ( 31607149) T wave morphology restitution during recovery from exercise (MTAG) ( 31607149) TPE interval (resting) ( 32386560) White matter integrity (bipolar disorder risk interaction) ( 23218918)	Bell's palsy ( 33602968) Central corneal thickness ( 32528159 31798171 29760442 30894546) Corneal hysteresis ( 30894546) Corneal resistance factor ( 31246245 30894546) Corneal structure ( 23291589) Coronary artery disease ( 29212778 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Glaucoma (primary open-angle) ( 33627673) Glycated hemoglobin levels ( 34059833 28898252) Heart rate ( 23583979) Height ( 28552196 25282103 25429064 23563607 31562340 33713608) Hip circumference adjusted for BMI ( 28552196 34021172 25673412) Hypertrophic cardiomyopathy ( 33495596 33495597) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Immature fraction of reticulocytes ( 32888494 27863252) Intraocular pressure ( 29617998 25173106 31798171 29785010 30054594 28073927 29235454) Intraocular pressure (Goldman correlated) ( 30894546) Keratoconus ( 33649486) Mean corpuscular hemoglobin ( 32888494) Myocardial infarction ( 33532862) Parkinson's disease ( 26227905) PR interval ( 32439900) Pulse pressure ( 30224653) Red cell distribution width ( 32888494 27863252 28957414) Refractive error ( 32231278) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Triptolide cytotoxicity ( 26121980) Waist circumference adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI (joint analysis main effects and smoking interaction) ( 28443625) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for BMI in non-smokers ( 28443625) Waist circumference adjusted for BMI in smokers ( 28443625) Waist circumference adjusted for body mass index ( 34021172 25673412 28448500) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		32 interacting genes: ACTN2 ARL2BP BANP CAMK2A CAMK2B CAMK2G CD5 CREM DNAL4 EPHA10 ERCC8 FAM171B FKBP1B FNDC3B GRIN2B HNMT IFNGR2 MOAP1 MRPL11 RNF4 RPS18 RPS4X SMARCB1 SPATA24 SRPK1 STAT1 TNPO2 TNPO3 TTC5 UBE2I VIM WASF3	52 interacting genes: ABHD11 ABHD8 ADGRF5 BBS2 BICRAL BRWD1 C10orf55 C10orf82 C19orf54 C22orf15 CAMK2D CAPN3 CEMP1 DAPL1 DUSP10 ERCC6 GAS2L3 HAPLN2 KLHDC7B KRTAP11-1 L3MBTL3 MBD3L1 MCCD1 MVP NDUFAB1 PIK3R4 POGZ POU6F2 PRKAA2 REL RUSC1 SPSB2 SRARP STPG4 SUOX TEKT5 TEPSIN TESMIN TEX43 TEX48 TIAM1 TOX4 TRAF2 TRIM35 TRIM42 TRIP13 TTN UBAP2 USP54 VAC14 YPEL3 ZMYND19
Entrez ID		817	64778
HPRD ID		09653	10943
Ensembl ID		ENSG00000145349	ENSG00000075420
Uniprot IDs		D6R938 E9PBG7 E9PF82 Q13557	Q53EP0
PDB IDs		2VN9 2W2C 2WEL 3GP2 5VLO 6AYW
Enriched GO Terms of Interacting Partners?
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