UNC93B1 and KLRC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		UNC93B1	KLRC1
Description		unc-93 homolog B1, TLR signaling regulator	killer cell lectin like receptor C1
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GO Annotations	Cellular Component	Golgi Membrane Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Early Phagosome	Plasma Membrane Integral Component Of Plasma Membrane Receptor Complex
	Molecular Function	Protein Binding Toll-like Receptor Binding	Transmembrane Signaling Receptor Activity Protein Binding MHC Class I Protein Complex Binding Carbohydrate Binding HLA-E Specific Inhibitory MHC Class Ib Receptor Activity Protein Antigen Binding
	Biological Process	Adaptive Immune Response Intracellular Protein Transport Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Defense Response To Virus	Negative Regulation Of T Cell Mediated Cytotoxicity Adaptive Immune Response CD8-positive, Gamma-delta Intraepithelial T Cell Differentiation Natural Killer Cell Inhibitory Signaling Pathway Cell Surface Receptor Signaling Pathway Innate Immune Response Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity
Pathways		Trafficking and processing of endosomal TLR UNC93B1 deficiency - HSE	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases
GWAS		Schizophrenia x sex interaction ( 34099189) Waist circumference adjusted for body mass index ( 34021172)	Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Blood protein levels ( 28240269) Granulocyte percentage of myeloid white cells ( 27863252) High light scatter reticulocyte count ( 32888494) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 27863252) Monocyte percentage of white cells ( 27863252) Reticulocyte count ( 32888494)
Interacting Genes		27 interacting genes: BEST2 CCDC107 CD79A CLDN7 CLPTM1 CREB3L1 EBP ERGIC3 FATE1 FFAR3 GPR101 GPR37L1 GPRC5D HHLA2 KLRC1 LDLRAD1 LEUTX LIME1 MBOAT7 MFF REEP1 SLC16A2 SLC35C2 SSMEM1 SYNDIG1 TM4SF18 TMEM237	46 interacting genes: ATP6V0B ATP6V0C BMP10 BRICD5 C3orf52 CD151 CD82 CGRRF1 CLDN11 CLEC2D CLEC7A CLRN2 CTXN3 CXCL14 CYB561A3 EMP1 EMP3 ERMP1 GJB2 GJB4 GJB6 GPR61 HLA-E KLRD1 KLRG1 LSMEM2 MAL MALL MS4A13 NKG7 PLP1 PMP22 PTPN11 PTPN6 SFTPC SUZ12 TMEM182 TMEM262 TMEM54 TMPPE TSPO2 UNC93B1 UPK1B VAMP5 VTI1B ZFPL1
Entrez ID		81622	3821
HPRD ID		12191	01192
Ensembl ID		ENSG00000110057	ENSG00000134545
Uniprot IDs		Q9H1C4	P26715
PDB IDs		7C76 7CYN	2RMX 2YU7 3BDW 3CDG 3CII
Enriched GO Terms of Interacting Partners?
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