ALX1 and CLIC3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ALX1	CLIC3
Description		ALX homeobox 1	chloride intracellular channel 3
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Golgi Apparatus Nuclear Body	Nucleus Cytoplasm Membrane Nuclear Body Chloride Channel Complex Extracellular Exosome
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity Sequence-specific Double-stranded DNA Binding	Voltage-gated Ion Channel Activity Chloride Channel Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis	Glutathione Metabolic Process Chloride Transport Signal Transduction Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport
Pathways
Drugs
Diseases
GWAS		Bone mineral density (Ward's triangle area) ( 27397699) Brain morphology (MOSTest) ( 32665545) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Nonsyndromic cleft lip ( 31609978) Nose size ( 27182965)
Interacting Genes		17 interacting genes: ALX4 APCS CLIC3 CREBBP EEF1D EP300 GRP IPO13 KAT5 KRTAP4-4 OR52L1 PACRGL RARA RBM45 SRA1 UROC1 ZNF300	35 interacting genes: AGR2 ALX1 ANKRD23 ANKRD55 APP C7orf31 C9orf24 DDIT4L DNM1 EFHC2 FAM166B GLYR1 INCA1 KATNBL1 KRT85 KRTAP13-3 LELP1 MAPK15 MBD3L1 MECOM MIA3 MSX2 POT1 PROSER2 SCML4 STMN3 TBC1D3 TBC1D3C TBC1D3K TEPSIN TLE5 VPS4A ZBTB42 ZC2HC1C ZNF620
Entrez ID		8092	9022
HPRD ID		03316	05941
Ensembl ID		ENSG00000180318	ENSG00000169583
Uniprot IDs		Q15699 V9HWA7	O95833 Q6FGP1
PDB IDs			3FY7 3KJY
Enriched GO Terms of Interacting Partners?
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