ALX1 and GRP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ALX1	GRP
Description		ALX homeobox 1	gastrin releasing peptide
Image		No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Golgi Apparatus Nuclear Body	Extracellular Region Extracellular Space Secretory Granule Lumen
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Protein Binding Protein Homodimerization Activity Sequence-specific Double-stranded DNA Binding	Signaling Receptor Binding Neuropeptide Hormone Activity Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Neural Crest Cell Migration Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Embryonic Skeletal System Morphogenesis	Signal Transduction Neuropeptide Signaling Pathway Social Behavior Psychomotor Behavior Response To External Biotic Stimulus Positive Regulation Of Peptide Hormone Secretion Positive Regulation Of Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway
Pathways			Peptide ligand-binding receptors Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) G alpha (q) signalling events
Drugs
Diseases
GWAS		Bone mineral density (Ward's triangle area) ( 27397699) Brain morphology (MOSTest) ( 32665545) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Nonsyndromic cleft lip ( 31609978) Nose size ( 27182965)	Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 25673413) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Medication use (drugs used in diabetes) ( 31015401) Pancreas volume ( 34128465) Pancreatic cancer ( 29422604 26098869) Pancreatic ductal adenocarcinoma ( 30541042) Triglyceride levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Type 2 diabetes ( 30297969) Venous thromboembolism ( 32232851)
Interacting Genes		17 interacting genes: ALX4 APCS CLIC3 CREBBP EEF1D EP300 GRP IPO13 KAT5 KRTAP4-4 OR52L1 PACRGL RARA RBM45 SRA1 UROC1 ZNF300	5 interacting genes: ALX1 DPP4 GRPR MEP1A MEP1B
Entrez ID		8092	2922
HPRD ID		03316	08845
Ensembl ID		ENSG00000180318	ENSG00000134443
Uniprot IDs		Q15699 V9HWA7	A0A140VJM7 P07492
PDB IDs			2N0B 2N0C 2N0D 2N0E 2N0F 2N0G 2N0H
Enriched GO Terms of Interacting Partners?
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