FLAD1 and COPS3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		FLAD1	COPS3
Description		flavin adenine dinucleotide synthetase 1	COP9 signalosome subunit 3
Image		No pdb structure
GO Annotations	Cellular Component	Mitochondrial Matrix Cytosol Plasma Membrane	Nucleoplasm Cytoplasm Cytosol COP9 Signalosome
	Molecular Function	FMN Adenylyltransferase Activity Protein Binding ATP Binding Identical Protein Binding	Protein Binding
	Biological Process	FAD Biosynthetic Process Riboflavin Metabolic Process	Protein Deneddylation In Utero Embryonic Development Ubiquitin-dependent Protein Catabolic Process Signal Transduction Response To Light Stimulus
Pathways		Vitamin B2 (riboflavin) metabolism	DNA Damage Recognition in GG-NER Formation of TC-NER Pre-Incision Complex Cargo recognition for clathrin-mediated endocytosis Neddylation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Prostate cancer ( 23535732) Red blood cell count ( 32888494) Refractive error ( 32231278)	Alanine aminotransferase levels ( 33547301) Mean corpuscular volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Neutrophil percentage of white cells ( 32888494) Reticulocyte count ( 32888494)
Interacting Genes		21 interacting genes: ANXA7 APTX CDKN1A CLVS2 COPS3 CRABP2 DNM2 FXR1 GEMIN4 GRB7 L3MBTL3 NIF3L1 NUDT21 PRTFDC1 RCC1 REL SDCBP SMN1 TCF4 TK1 TRIM23	32 interacting genes: ARAF ARF4 C17orf75 CEBPE COPS2 COPS4 COPS5 COPS6 COPS7A COPS7B COPS8 COPS9 CSNK2A1 CSNK2B CUL5 FLAD1 FRS3 GPS1 IKBKB IKBKG IL1RN IRF5 ITGB2 KRT80 LRP2BP MCPH1 MLF1 NABP1 PRXL2B RAF1 SOS1 TP53
Entrez ID		80308	8533
HPRD ID		17887	07262
Ensembl ID		ENSG00000160688	ENSG00000141030
Uniprot IDs		Q8NFF5	B4DN01 Q9UNS2
PDB IDs			4D10 4D18 4WSN 6R6H 6R7F 6R7H 6R7I 6R7N
Enriched GO Terms of Interacting Partners?
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