SPSB1 and ADPRH

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SPSB1	ADPRH
Description		splA/ryanodine receptor domain and SOCS box containing 1	ADP-ribosylarginine hydrolase
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GO Annotations	Cellular Component	Cytosol SCF Ubiquitin Ligase Complex	Extracellular Space Autophagosome Cytosol Recycling Endosome
	Molecular Function	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity	Magnesium Ion Binding ADP-ribosylarginine Hydrolase Activity GTPase Activator Activity Protein Binding Potassium Ion Binding
	Biological Process	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Cellular Protein Modification Process Intracellular Protein Transport Protein De-ADP-ribosylation Activation Of GTPase Activity Regulation Of Autophagosome Assembly
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Body shape index ( 34021172) Cognitive function ( 28093568) Dental caries ( 23064961) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Height ( 28552196 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immune response to anthrax vaccine ( 22658931) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Pulse pressure ( 27841878 30578418) Response to tocilizumab in rheumatoid arthritis ( 22491018) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 27841878 30578418) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Vitiligo ( 27723757)
Interacting Genes		14 interacting genes: ADPRH ATM DDX4 KDM1A MET NOS2 PAWR PRMT1 PRMT6 RASA1 SUV39H1 TRIM55 TRIM63 VWA5A	5 interacting genes: ACD SPSB1 SRPK1 SRPK2 TFCP2
Entrez ID		80176	141
HPRD ID		18106	04359
Ensembl ID		ENSG00000171621	ENSG00000144843
Uniprot IDs		A0A024R4G8 Q96BD6	A8K6X2 B4E341 P54922
PDB IDs		2JK9 3F2O	3HFW 6G28 6G2A 6IUX
Enriched GO Terms of Interacting Partners?
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