ADPRH and SPSB1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ADPRH	SPSB1
Description		ADP-ribosylarginine hydrolase	splA/ryanodine receptor domain and SOCS box containing 1
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GO Annotations	Cellular Component	Extracellular Space Autophagosome Cytosol Recycling Endosome	Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Magnesium Ion Binding ADP-ribosylarginine Hydrolase Activity GTPase Activator Activity Protein Binding Potassium Ion Binding	Protein Binding Ubiquitin Ligase-substrate Adaptor Activity
	Biological Process	Cellular Protein Modification Process Intracellular Protein Transport Protein De-ADP-ribosylation Activation Of GTPase Activity Regulation Of Autophagosome Assembly	Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways			Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Vitiligo ( 27723757)	Accelerated cognitive decline after conversion of mild cognitive impairment to Alzheimer's disease (Alzhiemer's diagnosis trajectory interaction) ( 28560309) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Body shape index ( 34021172) Cognitive function ( 28093568) Dental caries ( 23064961) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494) Height ( 28552196 31562340) Hip circumference adjusted for BMI ( 34021172) Hip index ( 34021172) Immune response to anthrax vaccine ( 22658931) Metabolite levels ( 23823483) Neutrophil percentage of granulocytes ( 27863252) Pulse pressure ( 27841878 30578418) Response to tocilizumab in rheumatoid arthritis ( 22491018) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 27841878 30578418) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		5 interacting genes: ACD SPSB1 SRPK1 SRPK2 TFCP2	14 interacting genes: ADPRH ATM DDX4 KDM1A MET NOS2 PAWR PRMT1 PRMT6 RASA1 SUV39H1 TRIM55 TRIM63 VWA5A
Entrez ID		141	80176
HPRD ID		04359	18106
Ensembl ID		ENSG00000144843	ENSG00000171621
Uniprot IDs		A8K6X2 B4E341 P54922	A0A024R4G8 Q96BD6
PDB IDs		3HFW 6G28 6G2A 6IUX	2JK9 3F2O
Enriched GO Terms of Interacting Partners?
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