EDC3 and EFHC2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)

		EDC3	EFHC2
Description		enhancer of mRNA decapping 3	EF-hand domain containing 2
Image
GO Annotations	Cellular Component	P-body Cytosol Membrane Cytoplasmic Ribonucleoprotein Granule	Microtubule Axoneme Ciliary Basal Body Mitotic Spindle
	Molecular Function	MRNA Binding Protein Binding Identical Protein Binding Phosphodiesterase Decapping Endonuclease Activity	Calcium Ion Binding Protein Binding Alpha-tubulin Binding
	Biological Process	Deadenylation-independent Decapping Of Nuclear-transcribed MRNA P-body Assembly RNA Phosphodiester Bond Hydrolysis, Endonucleolytic	Mitotic Cytokinesis Mitotic Spindle Organization Regulation Of Neuron Projection Development Cilium-dependent Cell Motility Cellular Response To Leukemia Inhibitory Factor
Pathways		mRNA decay by 5' to 3' exoribonuclease
Drugs
Diseases
GWAS		Caffeine consumption ( 21490707) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,3-dimethylxanthine (theophylline) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Coffee consumption (cups per day) ( 31837886) Craniofacial microsomia ( 26853712) Mean platelet volume ( 32888494)	Body mass index and diastolic blood pressure (bivariate analysis) ( 33539483) Glaucoma (primary open-angle) ( 33627673) Mean arterial pressure ( 29403010)
Interacting Genes		12 interacting genes: ANXA10 DDX6 EFHC2 LNX1 MIR15B OGT PIAS2 QARS1 REEP5 YWHAB YWHAG ZFP36	100 interacting genes: - AASDHPPT ARHGEF5 ARMC7 CABP2 CACNB4 CARD9 CCDC102B CCDC120 CCDC13 CCDC57 CCHCR1 CCNG2 CDKN2A CLIC3 COPE CPNE2 CPNE7 CYFIP1 DCLK1 DDX6 DGCR6 DRC7 EDC3 EFHC1 EGLN3 EMD ENKD1 ESRRG EXOC8 EXOSC5 FAM107A FAM124B FAM214B FAM221B FBXL19 GEM GLYCTK GOLGA1 GPKOW GRB2 GYS1 HDAC4 HGS HNRNPLL INPP5J JAKMIP2 KANK2 KCTD7 KIF9 L3MBTL2 LMNB2 LMO2 LNX1 LONRF1 MAGOHB MAPK9 MID2 MISP MYLIP MYO5B NCDN NCK2 NDOR1 NEK6 NFKBID NME7 NR3C1 PBLD PHF1 PIBF1 PICK1 PLOD3 POLR1C PRPF18 PTK6 QARS1 RAD51D RCOR3 RECK RHOBTB3 RUNX1T1 SNRNP25 SOGA1 SPATA18 SPG21 STK16 TBC1D1 TBC1D22B TEKT4 TRIM42 TRIM50 TSSK3 TUBGCP4 TXK U2AF1 USP2 ZBTB16 ZFHX3 ZZZ3
Entrez ID		80153	80258
HPRD ID		07954	06540
Ensembl ID		ENSG00000179151	ENSG00000183690
Uniprot IDs		Q96F86	Q5JST6
PDB IDs		2VC8 2WAX 2WAY 3D3J 3D3K 6S8S	2Z13 2Z14
Enriched GO Terms of Interacting Partners?
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