NR4A3 and SMOC1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		NR4A3	SMOC1
Description		nuclear receptor subfamily 4 group A member 3	SPARC related modular calcium binding 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex	Basement Membrane Extracellular Space
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Glucocorticoid Receptor Binding CAMP Response Element Binding Protein Homodimerization Activity	Calcium Ion Binding Protein Binding Heparin Binding Extracellular Matrix Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Gastrulation Pyruvate Oxidation Positive Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Glucose Transmembrane Transport Intracellular Receptor Signaling Pathway Animal Organ Regeneration Positive Regulation Of Mast Cell Cytokine Production Common Myeloid Progenitor Cell Proliferation Positive Regulation Of Mast Cell Activation By Fc-epsilon Receptor Signaling Pathway Mast Cell Degranulation Steroid Hormone Mediated Signaling Pathway Cellular Response To Leptin Stimulus Cellular Respiration Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Platelet-derived Growth Factor Receptor Signaling Pathway Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Type B Pancreatic Cell Proliferation Cellular Response To Corticotropin-releasing Hormone Stimulus Cellular Response To Catecholamine Stimulus Energy Homeostasis Positive Regulation Of Monocyte Aggregation Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration Positive Regulation Of Feeding Behavior	Eye Development Cell Differentiation Extracellular Matrix Organization Regulation Of Osteoblast Differentiation Limb Development
Pathways		RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function
Drugs		Dasatinib
Diseases
GWAS		Dental caries ( 23064961) Depression in smokers ( 30219690) Eosinophil percentage of white cells ( 32888494) Lung cancer ( 28604730) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 34127860)	Blood protein levels ( 30072576 29875488) Bone mineral density ( 24249740) Daytime sleep phenotypes ( 27126917) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Heel bone mineral density ( 30598549) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494) Peginterferon alfa-2a treatment response in chronic hepatitis B infection ( 30972912) Peripheral artery disease ( 31285632) Red blood cell traits ( 23222517) Red cell distribution width ( 32888494 27863252) Refractive error ( 32231278) Triglyceride levels ( 30108155) Tuberculosis ( 24057671)
Interacting Genes		43 interacting genes: ADAMTSL4 ALPP CDKN2D CHRD COPS5 CYP21A2 CYSRT1 EFEMP1 HSD3B7 KPRP KRTAP10-1 KRTAP10-5 KRTAP10-8 KRTAP12-3 KRTAP12-4 KRTAP4-11 KRTAP4-2 KRTAP4-4 KRTAP5-11 KRTAP5-3 KRTAP5-6 KRTAP5-9 KRTAP6-3 KRTAP9-2 KRTAP9-3 KRTAP9-8 LCE2B LCE2D MACO1 NECTIN2 PCSK5 PIN1 RECK RPS6KA1 SIX3 SMOC1 TRIM28 TSPAN4 UBE3A VASN VHL VWC2L ZNF330	12 interacting genes: COX16 CYSRT1 KRTAP1-1 KRTAP10-3 KRTAP10-8 NOTCH2NLA NR4A3 SYNJ2BP TCF4 TNC TTC9 VGLL3
Entrez ID		8013	64093
HPRD ID		02766	12244
Ensembl ID		ENSG00000119508	ENSG00000198732
Uniprot IDs		A0A024R168 Q92570	A0A024R6E0 Q9H4F8
PDB IDs
Enriched GO Terms of Interacting Partners?
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