ZNF212 and ATF4

Number of citations of the paper that reports this interaction (PubMedID 18255255)
9

Data Source:
BioGRID (two hybrid)

		ZNF212	ATF4
Description		zinc finger protein 212	activating transcription factor 4
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm	Chromatin Nucleus Nucleoplasm Cytoplasm Centrosome Plasma Membrane Nuclear Speck Protein-containing Complex Nuclear Periphery Neuron Projection Lewy Body Core ATF4-CREB1 Transcription Factor Complex ATF1-ATF4 Transcription Factor Complex CHOP-ATF4 Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Identical Protein Binding	Transcription Cis-regulatory Region Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Protein Binding Protein Kinase Binding Identical Protein Binding Leucine Zipper Domain Binding Sequence-specific DNA Binding Protein Heterodimerization Activity RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Bone Mineralization Endoplasmic Reticulum Unfolded Protein Response Response To Nutrient Levels Negative Regulation Of Translational Initiation In Response To Stress Circadian Regulation Of Gene Expression Cellular Response To Amino Acid Starvation Cellular Response To Oxidative Stress Cellular Response To UV Response To Endoplasmic Reticulum Stress Embryonic Hemopoiesis Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Oxidative Stress PERK-mediated Unfolded Protein Response Cellular Response To Glucose Starvation MRNA Transcription By RNA Polymerase II Positive Regulation Of Apoptotic Process Positive Regulation Of Neuron Apoptotic Process Regulation Of Osteoblast Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase I Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Synaptic Plasticity Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Arsenic-containing Substance Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Lens Fiber Cell Morphogenesis L-asparagine Metabolic Process Negative Regulation Of Cold-induced Thermogenesis Integrated Stress Response Signaling HRI-mediated Signaling Negative Regulation Of Oxidative Stress-induced Neuron Death Cellular Response To Dopamine Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress
Pathways		Generic Transcription Pathway	ATF4 activates genes in response to endoplasmic reticulum stress ATF4 activates genes in response to endoplasmic reticulum stress PERK regulates gene expression ATF6 (ATF6-alpha) activates chaperone genes ATF6 (ATF6-alpha) activates chaperone genes Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK4 (GCN2) to amino acid deficiency Response of EIF2AK1 (HRI) to heme deficiency Response of EIF2AK1 (HRI) to heme deficiency
Drugs			Pseudoephedrine
Diseases
GWAS		Metabolite levels ( 23823483)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Inflammatory bowel disease ( 23128233) Mean corpuscular volume ( 32888494)
Interacting Genes		31 interacting genes: - ATF3 ATF4 BYSL CREB3L2 CSK DPF2 DUSP6 FAM90A1 FHL2 FXR1 GAS8 GNL1 GYS1 HBP1 KANK2 MLH1 NFKBIA NKX2-3 PPARGC1B PRKAA2 PTP4A1 RND1 SAP30BP SF3A3 SUV39H2 ZNF3 ZNF331 ZNF408 ZNF783 ZZZ3	75 interacting genes: AP1M1 APH1A APP ASB7 ATF2 ATF3 BATF BATF2 BATF3 BFSP2 BTRC CCDC106 CEBPA CEBPB CEBPE CEBPG CEP83 CKAP4 CREB3 CREBBP CREBZF DAPK3 DDIT3 DISC1 DNMT3L EGLN3 EP300 FOS FOSL1 GABBR2 GCC1 GOLGA1 GOLGA8EP GOLGA8F GPS2 GTF2A1L GTF2B GTF2F2 HAUS7 HK3 JDP2 JUN JUNB KAT2B LDOC1 LMNB1 MAF MAFB MAP2K7 MDM2 MPZL2 NAP1L5 NDC80 NEK6 NFE2 NFE2L1 NFE2L2 NFKBIA NLGN3 POLR2C PTCD3 REPS1 RPS6 SAPCD2 SNAP29 SRA1 TARS3 TBP TGM2 TREX2 TRIB3 TRIM24 TTR ZNF212 ZNF226
Entrez ID		7988	468
HPRD ID		03859	06817
Ensembl ID		ENSG00000170260	ENSG00000128272
Uniprot IDs		A0A090N8N3 B3KQE6 Q9UDV6	P18848
PDB IDs			1CI6
Enriched GO Terms of Interacting Partners?
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