NEK11 and NEK2

Number of citations of the paper that reports this interaction (PubMedID 15161910)
15

Data Source:
HPRD (in vitro, in vivo)

		NEK11	NEK2
Description		NIMA related kinase 11	NIMA related kinase 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome	Kinetochore Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Microtubule Midbody Protein-containing Complex
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Protein Phosphorylation Chromosome Segregation Histone Phosphorylation Mitotic Intra-S DNA Damage Checkpoint Signaling Intracellular Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Blastocyst Development Protein Phosphorylation Chromosome Segregation Regulation Of Mitotic Nuclear Division Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Binding Regulation Of Mitotic Centrosome Separation Protein Autophosphorylation Spindle Assembly Centrosome Separation Cell Division Meiotic Cell Cycle Positive Regulation Of Telomerase Activity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Telomere Capping
Pathways			APC-Cdc20 mediated degradation of Nek2A Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		Dabrafenib Fostamatinib	5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamide Fostamatinib
Diseases
GWAS		Carotid intima media thickness ( 26343869) Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334) Hippocampal sclerosis ( 25188341) Obsessive-compulsive traits ( 33531474) Phenylephrine infusion rate during anesthesia ( 31455332) Weight ( 28552196)	Red cell distribution width ( 32888494 27863252 28957414) Serum alkaline phosphatase levels ( 33547301)
Interacting Genes		6 interacting genes: ACAD11 APP BLM MFHAS1 MYC NEK2	41 interacting genes: ADORA1 ARHGEF11 ATF3 CCDC85A CD46 CDC20 CEP250 CHGA CNTN2 CSN2 CTNNB1 DCTN1 DUSP10 EDRF1 EIF4A2 FLVCR1 FZR1 GIT1 IFT140 IMMT KCNA4 KIAA0930 MAD1L1 MAPK1 MCC NDC80 NEK11 NENF PDE4DIP PLCB2 PPP1CA PPP1CC PPP1R2 PPP2R5A PRKN PROX1 PTPRD SMURF1 SPTBN4 TCF25 TPM3
Entrez ID		79858	4751
HPRD ID		14821	04953
Ensembl ID		ENSG00000114670	ENSG00000117650
Uniprot IDs		B4DDN2 B4DM56 E9PHI8 Q8NG66	F6U4U2 P51955
PDB IDs			2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE 5M51 5M53 5M55 5M57 6SGD 6SGH 6SGI 6SGK 6SK9 6TM5
Enriched GO Terms of Interacting Partners?
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