NEK2 and NEK11

Number of citations of the paper that reports this interaction (PubMedID 15161910)
15

Data Source:
HPRD (in vitro, in vivo)

		NEK2	NEK11
Description		NIMA related kinase 2	NIMA related kinase 11
Image			No pdb structure
GO Annotations	Cellular Component	Kinetochore Condensed Nuclear Chromosome Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome Cytosol Microtubule Midbody Protein-containing Complex	Nucleus Nucleoplasm Nucleolus Cytoplasm Centrosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Phosphatase Binding Metal Ion Binding Protein Serine Kinase Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Metal Ion Binding Protein Serine Kinase Activity
	Biological Process	Mitotic Sister Chromatid Segregation Mitotic Cell Cycle Blastocyst Development Protein Phosphorylation Chromosome Segregation Regulation Of Mitotic Nuclear Division Positive Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Binding Regulation Of Mitotic Centrosome Separation Protein Autophosphorylation Spindle Assembly Centrosome Separation Cell Division Meiotic Cell Cycle Positive Regulation Of Telomerase Activity Regulation Of Attachment Of Spindle Microtubules To Kinetochore Mitotic Spindle Assembly Negative Regulation Of Centriole-centriole Cohesion Positive Regulation Of Telomere Capping	Protein Phosphorylation Chromosome Segregation Histone Phosphorylation Mitotic Intra-S DNA Damage Checkpoint Signaling Intracellular Signal Transduction Regulation Of Mitotic Cell Cycle Phase Transition
Pathways		APC-Cdc20 mediated degradation of Nek2A Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs		5-[(Z)-(5-Chloro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-N,2,4-trimethyl-1H-pyrrole-3-carboxamide Fostamatinib	Dabrafenib Fostamatinib
Diseases
GWAS		Red cell distribution width ( 32888494 27863252 28957414) Serum alkaline phosphatase levels ( 33547301)	Carotid intima media thickness ( 26343869) Hip bone mineral density and total body fat mass (bivariate analysis) ( 32963334) Hippocampal sclerosis ( 25188341) Obsessive-compulsive traits ( 33531474) Phenylephrine infusion rate during anesthesia ( 31455332) Weight ( 28552196)
Interacting Genes		41 interacting genes: ADORA1 ARHGEF11 ATF3 CCDC85A CD46 CDC20 CEP250 CHGA CNTN2 CSN2 CTNNB1 DCTN1 DUSP10 EDRF1 EIF4A2 FLVCR1 FZR1 GIT1 IFT140 IMMT KCNA4 KIAA0930 MAD1L1 MAPK1 MCC NDC80 NEK11 NENF PDE4DIP PLCB2 PPP1CA PPP1CC PPP1R2 PPP2R5A PRKN PROX1 PTPRD SMURF1 SPTBN4 TCF25 TPM3	6 interacting genes: ACAD11 APP BLM MFHAS1 MYC NEK2
Entrez ID		4751	79858
HPRD ID		04953	14821
Ensembl ID		ENSG00000117650	ENSG00000114670
Uniprot IDs		F6U4U2 P51955	B4DDN2 B4DM56 E9PHI8 Q8NG66
PDB IDs		2JAV 2W5A 2W5B 2W5H 2WQO 2XK3 2XK4 2XK6 2XK7 2XK8 2XKC 2XKD 2XKE 2XKF 2XNM 2XNN 2XNO 2XNP 4A4X 4AFE 5M51 5M53 5M55 5M57 6SGD 6SGH 6SGI 6SGK 6SK9 6TM5
Enriched GO Terms of Interacting Partners?
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