HECTD3 and TRIOBP

Number of citations of the paper that reports this interaction (PubMedID 18194665)
10

Data Source:
BioGRID (two hybrid, pull down, affinity chromatography technology)

		HECTD3	TRIOBP
Description		HECT domain E3 ubiquitin protein ligase 3	TRIO and F-actin binding protein
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Microtubule Organizing Center Focal Adhesion Actin Cytoskeleton Midbody Stereocilium Base
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Syntaxin Binding	Small GTPase Binding Ubiquitin Protein Ligase Binding Myosin II Binding Actin Filament Binding
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	Actin Filament Organization Cell Cycle Sensory Perception Of Sound Actin Modification Barbed-end Actin Filament Capping Cell Division Auditory Receptor Cell Stereocilium Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Adult hearing difficulty ( 31564434) Age-related hearing impairment ( 27764096) Age-related hearing impairment (low/mid frequency) ( 31645637) Basophil count ( 32888494) Brain morphology (MOSTest) ( 32665545) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 33627673) Intraocular pressure ( 29617998 29785010 31959993 30054594) Lateral ventricular volume in normal aging ( 30258056) Optic cup area ( 25631615 28073927) Pulse pressure ( 30224653) Total cholesterol change in response to fenofibrate in statin-treated type 2 diabetes ( 28736931) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993)
Interacting Genes		8 interacting genes: BRCA1 CASP8 CASP9 PPL TP53 TRIOBP UBE2D2 ZDHHC17	10 interacting genes: DNAL4 FXR1 FXR2 GTF2H1 HECTD3 IKBKG PLK1 POLR1C TSC1 VIM
Entrez ID		79654	11078
HPRD ID		13383	11028
Ensembl ID		ENSG00000126107	ENSG00000100106
Uniprot IDs		A1A4G1 B3KU34 Q5T447	Q9H2D6
PDB IDs
Enriched GO Terms of Interacting Partners?
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