AIMP2 and PLEKHF2

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		AIMP2	PLEKHF2
Description		aminoacyl tRNA synthetase complex interacting multifunctional protein 2	pleckstrin homology and FYVE domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol Membrane Aminoacyl-tRNA Synthetase Multienzyme Complex	Endoplasmic Reticulum Transport Vesicle Early Endosome Membrane
	Molecular Function	Protein Binding Molecular Adaptor Activity	Protein Binding Phosphatidylinositol Binding Metal Ion Binding
	Biological Process	Translation Apoptotic Process Negative Regulation Of Cell Population Proliferation Positive Regulation Of Protein Ubiquitination Type II Pneumocyte Differentiation Protein-containing Complex Assembly Positive Regulation Of Neuron Death Positive Regulation Of Aminoacyl-tRNA Ligase Activity	Protein Transport
Pathways		Selenoamino acid metabolism Cytosolic tRNA aminoacylation
Drugs
Diseases
GWAS		High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252)	Radiation response ( 20923822)
Interacting Genes		105 interacting genes: ACTB AIMP1 APP BCAS2 BEX3 BLOC1S4 BRME1 BYSL C1orf216 CBY2 CCDC153 CEP126 CHD3 DARS1 DARS2 DEAF1 DISC1 DSN1 EPRS1 EPS8 EXOC8 FGB FHL3 FUBP1 GYS1 HSPA1A HSPA4 ICE1 KARS1 KDR KLC2 KRT31 KRT33B KRT34 KRT36 LMO2 LMO3 LNX1 LUC7L2 MAD1L1 MATR3 MCF2L MIR106A MIR107 MIR122 MIR128-1 MIR128-2 MIR138-2 MIR15A MIR18A MIR199A1 MIR19A MIR19B1 MIR19B2 MIR200C MIR205 MIR20A MIR20B MIR21 MIR214 MIR221 MIR222 MIR25 MIR29A MIR34A MIR34B MIR34C MIR429 MIR451A MIR7-1 MIR7-2 MIR92A2 MIRLET7A1 MIRLET7A2 MIRLET7A3 MIRLET7B MIRLET7C MIRLET7E MIRLET7F1 MIRLET7F2 MIRLET7I MIS18A NDEL1 NECAB2 NTAQ1 PFDN6 PLEKHF2 PPP2R1A PRKAA2 PRKN PSME1 RABEP1 SBK3 SLU7 SMURF2 SPATA18 TANK TCP11 TERF2IP TEX12 TFIP11 TRAF2 TRMT2A ZC3H12A ZGPAT	176 interacting genes: ABCG4 ACY3 ADAP1 AIDA AIMP2 ANO9 APP APPL1 ARID4B ARL14EP ASPH BARHL2 BCAS2 BCAS3 BEND7 BLOC1S6 BOD1 BRD7 BSCL2 C11orf45 C1orf35 C3 CAVIN2 CBX8 CCDC146 CCDC172 CCDC25 CCDC85B CDC20B CEP44 CERK CGGBP1 CHCHD2 CHIC2 COX5B CRYBA1 DAZAP2 DMRT3 DNAAF11 DOCK2 DOCK3 DPPA4 DRAP1 DTX2 DUSP4 DUT EIF3C EML2 ESRP1 EXOC7 FAH FBXO28 FBXW5 FGF13 FHL3 FLNA FOXA1 FRMD8 GAGE12G GAGE2E GEM GFER GLUL GNMT GPBP1 GPBP1L1 GRAMD4 GTPBP2 HEBP2 HEY1 HSPB7 INO80 KCNAB3 KRTAP10-10 KRTAP5-4 L3MBTL3 LDOC1 MAGI2 MAP2K1 MAX MBIP MBP MEAF6 MFAP1 MIDN MPP4 MRI1 NDUFA5 NFIA NKG7 NONO NPM2 NSD2 NUDT2 NUTM1 P2RX7 PACSIN1 PAK1IP1 PDK4 PDP1 PEX2 PIK3R3 PPCDC PPP1R18 PRDM14 PRKAG1 PRKAR1A PRPSAP1 PTPN3 PWWP2A RAB28 RAB39A RABAC1 RADX RARA RASGEF1B RGS10 RGS8 RPAP2 RPE RPRM RPS21 RSPO2 RTN1 RTN3 RTN4 S100A1 S100A13 SAMD11 SCYL1 SEC14L4 SEPTIN2 SEPTIN5 SEPTIN6 SETBP1 SFN SNRNP35 SOST SPATA24 SPEF1 SPON2 STAMBPL1 SYT16 TBCEL TBX3 TCEANC TCN2 THAP10 THG1L TNFAIP8 TNFAIP8L1 TP53BP2 TRAF6 TRAM1L1 TRAPPC3 TRIAP1 TRIM22 TSC22D3 TTC9C TXNL4B UBE2Z UGP2 USF1 XCR1 XRN2 YIF1A YY1 ZBTB6 ZDHHC24 ZFYVE26 ZNF165 ZNF250 ZNF263 ZNF398 ZNF439 ZNF581
Entrez ID		7965	79666
HPRD ID		02915	15147
Ensembl ID		ENSG00000106305	ENSG00000175895
Uniprot IDs		A0A024QZY1 A8MU58 Q13155	Q9H8W4
PDB IDs		4DPG 4YCU 4YCW 5A1N 5A34 5A5H 5Y6L 6ILD 6IY6 6JPV 6K39
Enriched GO Terms of Interacting Partners?
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