MBOAT7 and UNC93B1

Number of citations of the paper that reports this interaction (PubMedID 21903422)
143

Data Source:
BioGRID (pull down)

		MBOAT7	UNC93B1
Description		membrane bound O-acyltransferase domain containing 7	unc-93 homolog B1, TLR signaling regulator
Image		No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Mitochondria-associated Endoplasmic Reticulum Membrane	Golgi Membrane Lysosome Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane Early Phagosome
	Molecular Function	1-acylglycerol-3-phosphate O-acyltransferase Activity Protein Binding O-acyltransferase Activity Acyltransferase Activity 2-acylglycerol-3-phosphate O-acyltransferase Activity Lysophospholipid Acyltransferase Activity	Protein Binding Toll-like Receptor Binding
	Biological Process	Phosphatidylinositol Biosynthetic Process Ventricular System Development Layer Formation In Cerebral Cortex Lipid Modification Phosphatidylinositol Acyl-chain Remodeling Phosphatidylcholine Acyl-chain Remodeling Regulation Of Triglyceride Metabolic Process	Adaptive Immune Response Intracellular Protein Transport Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 7 Signaling Pathway Toll-like Receptor 9 Signaling Pathway Innate Immune Response Defense Response To Virus
Pathways		Acyl chain remodelling of PI	Trafficking and processing of endosomal TLR UNC93B1 deficiency - HSE
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 33730874) Blood metabolite levels ( 24816252) Blood metabolite ratios ( 24816252) Cirrhosis (alcohol related) ( 26482880 32853455) Liver enzyme levels (alkaline phosphatase) ( 33972514) Obesity-related traits ( 23251661) Phosphatidylinositol levels ( 31551469) Serum alkaline phosphatase levels ( 33547301) Serum metabolite levels ( 33031748)	Schizophrenia x sex interaction ( 34099189) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		7 interacting genes: ADRA1A BDKRB1 MAPK6 SHANK3 STING1 UBC UNC93B1	27 interacting genes: BEST2 CCDC107 CD79A CLDN7 CLPTM1 CREB3L1 EBP ERGIC3 FATE1 FFAR3 GPR101 GPR37L1 GPRC5D HHLA2 KLRC1 LDLRAD1 LEUTX LIME1 MBOAT7 MFF REEP1 SLC16A2 SLC35C2 SSMEM1 SYNDIG1 TM4SF18 TMEM237
Entrez ID		79143	81622
HPRD ID		06925	12191
Ensembl ID		ENSG00000125505	ENSG00000110057
Uniprot IDs		Q96N66	Q9H1C4
PDB IDs			7C76 7CYN
Enriched GO Terms of Interacting Partners?
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