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UBE2I and SREBF2
Number of citations of the paper that reports this interaction (PubMedID
12615929
)
36
Data Source:
HPRD
(in vitro, in vivo)
UBE2I
SREBF2
Description
ubiquitin conjugating enzyme E2 I
sterol regulatory element binding transcription factor 2
Image
GO Annotations
Cellular Component
Synaptonemal Complex
Nucleus
Nuclear Envelope
Nucleoplasm
Cytoplasm
Cytosol
PML Body
Transferase Complex
Sumoylated E2 Ligase Complex
Golgi Membrane
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Cytosol
ER To Golgi Transport Vesicle Membrane
SREBP-SCAP-Insig Complex
Intracellular Membrane-bounded Organelle
Molecular Function
Transcription Coregulator Binding
RNA Binding
Protein Binding
ATP Binding
Transcription Factor Binding
SUMO Transferase Activity
Enzyme Binding
HLH Domain Binding
Small Protein Activating Enzyme Binding
SUMO Conjugating Enzyme Activity
RING-like Zinc Finger Domain Binding
C-8 Sterol Isomerase Activity
RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding
DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific
Protein Binding
Protein C-terminus Binding
Protein Dimerization Activity
E-box Binding
Sequence-specific Double-stranded DNA Binding
Biological Process
Negative Regulation Of Transcription By RNA Polymerase II
Cellular Protein Modification Process
Ubiquitin-dependent Protein Catabolic Process
Chromosome Segregation
Mitotic Nuclear Membrane Reassembly
Protein Sumoylation
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Negative Regulation Of Transcription, DNA-templated
Cell Division
Positive Regulation Of SUMO Transferase Activity
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Transcription By RNA Polymerase II
Lipid Metabolic Process
Cholesterol Metabolic Process
Regulation Of Notch Signaling Pathway
Cellular Response To Starvation
Positive Regulation Of Cholesterol Storage
SREBP Signaling Pathway
Cholesterol Homeostasis
Positive Regulation Of Transcription By RNA Polymerase II
Cellular Response To Low-density Lipoprotein Particle Stimulus
Cellular Response To Laminar Fluid Shear Stress
Negative Regulation Of Cholesterol Efflux
Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II
Regulation Of Autophagy Of Mitochondrion
Positive Regulation Of Protein Targeting To Mitochondrion
Pathways
Meiotic synapsis
Vitamin D (calciferol) metabolism
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMO is transferred from E1 to E2 (UBE2I, UBC9)
SUMOylation of DNA damage response and repair proteins
SUMO E3 ligases SUMOylate target proteins
SUMOylation of transcription factors
SUMOylation of transcription factors
SUMOylation of ubiquitinylation proteins
SUMOylation of transcription cofactors
SUMOylation of transcription cofactors
SUMOylation of SUMOylation proteins
SUMOylation of intracellular receptors
SUMOylation of intracellular receptors
SUMOylation of chromatin organization proteins
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA replication proteins
SUMOylation of DNA methylation proteins
SUMOylation of DNA methylation proteins
SUMOylation of immune response proteins
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks
Processing of DNA double-strand break ends
Formation of Incision Complex in GG-NER
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Negative regulation of activity of TFAP2 (AP-2) family transcription factors
Postmitotic nuclear pore complex (NPC) reformation
Maturation of nucleoprotein
Maturation of nucleoprotein
Regulation of cholesterol biosynthesis by SREBP (SREBF)
Regulation of cholesterol biosynthesis by SREBP (SREBF)
PPARA activates gene expression
Activation of gene expression by SREBF (SREBP)
Activation of gene expression by SREBF (SREBP)
Transcriptional regulation of white adipocyte differentiation
EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs
Diseases
GWAS
Idiopathic dilated cardiomyopathy (
29495422
)
Monocyte percentage of white cells (
32888494
)
Pulse pressure (
30224653
30578418
)
Refractive error (
32231278
)
Systolic blood pressure (
30578418
)
White blood cell count (
32888494
)
Alanine aminotransferase levels (
33547301
)
Amyotrophic lateral sclerosis (sporadic) (
24529757
)
Birth weight (
31043758
27680694
)
Caffeine consumption from tea (
33287642
)
General cognitive ability (
29844566
)
Processed meat consumption (
32066663
)
Refractive error (
32231278
)
Schizophrenia (
25056061
29483656
)
Interacting Genes
474 interacting genes:
-
ACTB
ADAR
ADARB1
ADD3
AGR2
AGTRAP
AKAP17A
ANAPC4
ANXA1
APEX1
APP
AR
ARHGDIA
ARL13B
ARL6IP1
ARNT
ARNTL
ATF2
ATF3
ATF7IP
ATXN1
AURKA
AURKB
BANP
BCAM
BCL11A
BCL2L1
BEND5
BHLHE40
BIRC3
BIRC7
BLM
BLMH
BMI1
BTBD3
C18orf25
CALU
CAMK2D
CAMK2G
CAMSAP2
CARD9
CARM1
CASP2
CASP8AP2
CBLC
CBS
CBX4
CCDC6
CD2AP
CDC37
CDCA8
CDH4
CDKN1B
CDR2L
CEBPD
CEBPE
CENPX
CFL2
CFTR
CHD3
CHD4
CHFR
CHMP1A
CHMP4B
CHUK
CLDN2
CLK2
COG1
CORO2A
CREB1
CREBBP
CREBL2
CREM
CSGALNACT2
CSK
CSNK2B
CTBP2
CTNNA1
CYP4F2
DACH1
DAXX
DCTD
DDX21
DDX24
DDX39A
DDX39B
DDX5
DES
DHX9
DMC1
DNM1
DNMT3A
DNMT3B
DPPA2
DPYSL2
DRG1
DTX3L
DZIP3
EDARADD
EDF1
EGR2
EIF2AK2
EIF2B1
ELK1
EP300
ERCC6
ESR1
ETS1
ETV1
ETV6
EXO1
EXOSC9
FADD
FAF1
FAM118A
FANCM
FAS
FATE1
FHIT
FHL3
FLI1
FMR1
FOS
FOXL2
FOXM1
GCM1
GIPC2
GLUL
GMCL1
GMCL2
GMEB1
GMEB2
GOLGA1
GOLGA2
GOLGB1
GRIP1
GTF2I
H4-16
HABP4
HDAC1
HDAC4
HDAC5
HDAC7
HGS
HIC1
HIF1A
HIPK1
HIPK2
HIPK3
HIRA
HMBOX1
HMGB1
HMGN2
HMGXB4
HNF4A
HNRNPC
HNRNPCL1
HNRNPD
HNRNPK
HNRNPLL
HNRNPM
HNRNPU
HSF1
HSF2
HSF2BP
IKBKG
IKZF1
IKZF3
IKZF5
IMPDH1
IPO13
IQGAP1
JUN
JUNB
KAT2A
KAT6B
KCNA5
KCNK1
KCTD1
KDM1A
KHSRP
KLF3
KLF5
KLHL12
KLHL2
KMT5A
KRT19
KRTAP5-2
KRTAP5-4
KRTAP5-9
KTN1
LATS1
LCE1D
LCE1F
LCE2C
LCE3B
LCE5A
LMNA
LMNB1
LMO2
LNX2
LONRF1
LRSAM1
MALL
MAP2K1
MAP3K1
MAP3K5
MAPK1IP1L
MARCHF5
MAT2A
MATR3
MDM2
MECOM
MED7
MEF2C
MGRN1
MIPOL1
MITF
MKRN3
MLX
MRTFA
MTA1
MYB
MYBBP1A
MYH9
NACC1
NAF1
NAT10
NCOR2
NFKBIA
NIN
NMI
NOL6
NONO
NOP2
NOP56
NOP58
NOX5
NR1D2
NR1H2
NR1H3
NR1I2
NR3C1
NR3C2
NR5A1
NR5A2
NSD3
NUDCD3
NVL
PAICS
PARK7
PARP1
PAX5
PCNA
PDLIM7
PDPK1
PDZK1
PELI1
PEX10
PHC1
PIAS1
PIAS2
PIAS3
PIAS4
PIM1
PLAAT4
PLAGL1
PML
POLR1H
POU1F1
POU2F1
PPARA
PPARG
PPARGC1A
PPCDC
PPM1J
PRKAA2
PRKDC
PROP1
PRPF40A
PRPF8
PRPSAP1
PSMC3
PSMC6
PSME3
PTEN
PUF60
RABAC1
RAD18
RAD51
RAD52
RAD54B
RAD54L2
RANBP2
RANGAP1
RB1
RBBP5
RBBP6
RBM14
RBM25
RC3H2
RCBTB2
RFPL3
RHOXF2
RIPK2
RNF10
RNF111
RNF115
RNF128
RNF133
RNF144B
RNF151
RNF185
RNF4
RNF40
RORB
RPL11
RPL7
RPL8
RPRD1B
RPS3A
RPS6KA6
RUSF1
RWDD3
RXRA
SAE1
SALL1
SART1
SATB1
SCNN1A
SEMA6A
SEPTIN1
SETBP1
SETDB1
SETX
SFPQ
SH3KBP1
SIAH1
SIAH2
SIRT1
SKIL
SLC2A1
SLC2A4
SLX4
SMAD4
SNAI2
SND1
SNIP1
SNRNP200
SOCS6
SOX10
SOX4
SOX5
SOX6
SOX9
SP100
SP3
SPECC1L
SPOP
SREBF1
SREBF2
SRF
SRSF4
SSRP1
STAT1
STMN2
STX1A
STX1B
STX2
SUMO1
SUMO1P1
SUMO2
SUMO3
SUPT7L
SUZ12
SYMPK
TAB2
TAF1
TAF10
TAF12
TAF5
TBL1X
TBL1XR1
TBP
TCERG1
TCF3
TCF4
TDG
TDP2
TERF2
TFAP2A
TFAP2B
TFAP2C
TFCP2
TFG
THAP1
THRA
THRB
TIGD3
TLK2
TNFRSF1A
TOP1
TOP2A
TOP2B
TOPORS
TP53
TP63
TP73
TRAF2
TRAF3
TRAF4
TRAF6
TRIM21
TRIM23
TRIM24
TRIM27
TRIM28
TRIM29
TRIM3
TRIM38
TRIM41
TRIM54
TRIM63
TRIM72
TRIP13
TRPS1
TSHZ2
TSN
TSNAX
TTN
TXLNB
UBA2
UBE2K
UBQLN1
UBQLN2
UBXN1
UCHL1
UNC119
USP25
VENTX
VEZF1
VHL
WNK1
WT1
WWP2
XBP1
XIAP
XRCC1
XRCC5
ZBED1
ZBTB1
ZBTB16
ZBTB2
ZBTB26
ZBTB7A
ZBTB8A
ZBTB9
ZC3H10
ZCCHC12
ZCCHC7
ZEB2
ZG16
ZIC1
ZMYM2
ZNF106
ZNF24
ZNF408
ZNF446
ZNF451
ZNF618
ZNF646
ZNF837
ZNRD2
50 interacting genes:
ABLIM1
ABLIM2
ARHGEF1
ARRB1
ATF7IP
ATXN1
AURKA
CASP3
CASP8AP2
COPS5
CREB1
CREBBP
EGR1
EP300
FHL2
FHL3
GOLGB1
HNF4A
HSPA5
INSIG1
INSIG2
ITGB4
KLF13
KPNB1
LINC00839
LZTR1
MAPK1
MAPK3
MRPS6
MTNR1B
NAE1
NFYA
NFYC
OS9
PIAS1
PIAS2
PIAS3
PSMD4
RAB11B
SCAP
SLC4A4
SMAD3
SP1
SPTBN1
SUMO1
TTC1
UBE2I
ZDHHC17
ZMYM2
ZYX
Entrez ID
7329
6721
HPRD ID
09045
02726
Ensembl ID
ENSG00000103275
ENSG00000198911
Uniprot IDs
A8K503
B0QYN7
P63279
A0A024R1Q0
Q12772
PDB IDs
1A3S
1KPS
1Z5Q
1Z5S
2GRN
2GRO
2GRP
2GRQ
2GRR
2O25
2PE6
2PX9
2XWU
3A4S
3UIN
3UIO
3UIP
4W5V
4Y1L
5D2M
5F6D
5F6E
5F6U
5F6V
5F6W
5F6X
5F6Y
5FQ2
6SYF
1UKL
Enriched GO Terms of Interacting Partners
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