UBE2I and WNK1

Number of citations of the paper that reports this interaction (PubMedID 15561718)
52

Data Source:
BioGRID (enzymatic study)

		UBE2I	WNK1
Description		ubiquitin conjugating enzyme E2 I	WNK lysine deficient protein kinase 1
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GO Annotations	Cellular Component	Synaptonemal Complex Nucleus Nuclear Envelope Nucleoplasm Cytoplasm Cytosol PML Body Transferase Complex Sumoylated E2 Ligase Complex	Cytoplasm Cytosol Membrane
	Molecular Function	Transcription Coregulator Binding RNA Binding Protein Binding ATP Binding Transcription Factor Binding SUMO Transferase Activity Enzyme Binding HLH Domain Binding Small Protein Activating Enzyme Binding SUMO Conjugating Enzyme Activity RING-like Zinc Finger Domain Binding	Magnesium Ion Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Chloride Channel Inhibitor Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Phosphatase Binding Protein Serine/threonine Kinase Inhibitor Activity Protein Kinase Activator Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cellular Protein Modification Process Ubiquitin-dependent Protein Catabolic Process Chromosome Segregation Mitotic Nuclear Membrane Reassembly Protein Sumoylation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of Transcription, DNA-templated Cell Division Positive Regulation Of SUMO Transferase Activity	Regulation Of Sodium Ion Transport Positive Regulation Of Systemic Arterial Blood Pressure Protein Phosphorylation Ion Transport Signal Transduction Negative Regulation Of Sodium Ion Transport Positive Regulation Of T Cell Chemotaxis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Activation Of Protein Kinase Activity Negative Regulation Of Cell-cell Adhesion Mediated By Integrin Negative Regulation Of Kinase Activity Negative Regulation Of Heterotypic Cell-cell Adhesion Negative Regulation Of GTPase Activity Intracellular Signal Transduction Chemokine (C-C Motif) Ligand 21 Signaling Pathway Protein Autophosphorylation Neuron Development Regulation Of Cellular Process Ion Homeostasis T Cell Receptor Signaling Pathway Cellular Response To Calcium Ion Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of Canonical Wnt Signaling Pathway Lymphocyte Migration Into Lymph Node Negative Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Potassium Ion Import Across Plasma Membrane Regulation Of Cation Transmembrane Transport Cellular Response To Chemokine Positive Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Meiotic synapsis Vitamin D (calciferol) metabolism SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMO is transferred from E1 to E2 (UBE2I, UBC9) SUMOylation of DNA damage response and repair proteins SUMO E3 ligases SUMOylate target proteins SUMOylation of transcription factors SUMOylation of transcription factors SUMOylation of ubiquitinylation proteins SUMOylation of transcription cofactors SUMOylation of transcription cofactors SUMOylation of SUMOylation proteins SUMOylation of intracellular receptors SUMOylation of intracellular receptors SUMOylation of chromatin organization proteins SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA replication proteins SUMOylation of DNA replication proteins SUMOylation of DNA methylation proteins SUMOylation of DNA methylation proteins SUMOylation of immune response proteins Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER Negative regulation of activity of TFAP2 (AP-2) family transcription factors Negative regulation of activity of TFAP2 (AP-2) family transcription factors Postmitotic nuclear pore complex (NPC) reformation Maturation of nucleoprotein Maturation of nucleoprotein	Stimuli-sensing channels
Drugs
Diseases
GWAS		Idiopathic dilated cardiomyopathy ( 29495422) Monocyte percentage of white cells ( 32888494) Pulse pressure ( 30224653 30578418) Refractive error ( 32231278) Systolic blood pressure ( 30578418) White blood cell count ( 32888494)	Adult body size ( 32376654) Blood protein levels ( 29875488) Body mass index ( 25673413 29273807) Body size at age 10 ( 32376654) Eosinophil counts ( 27863252) Eosinophil percentage of white cells ( 27863252) Lung cancer ( 28604730) Lung cancer in ever smokers ( 28604730) Manganese levels ( 26025379) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Squamous cell lung carcinoma ( 28604730) Stroke ( 19369658)
Interacting Genes		474 interacting genes: - ACTB ADAR ADARB1 ADD3 AGR2 AGTRAP AKAP17A ANAPC4 ANXA1 APEX1 APP AR ARHGDIA ARL13B ARL6IP1 ARNT ARNTL ATF2 ATF3 ATF7IP ATXN1 AURKA AURKB BANP BCAM BCL11A BCL2L1 BEND5 BHLHE40 BIRC3 BIRC7 BLM BLMH BMI1 BTBD3 C18orf25 CALU CAMK2D CAMK2G CAMSAP2 CARD9 CARM1 CASP2 CASP8AP2 CBLC CBS CBX4 CCDC6 CD2AP CDC37 CDCA8 CDH4 CDKN1B CDR2L CEBPD CEBPE CENPX CFL2 CFTR CHD3 CHD4 CHFR CHMP1A CHMP4B CHUK CLDN2 CLK2 COG1 CORO2A CREB1 CREBBP CREBL2 CREM CSGALNACT2 CSK CSNK2B CTBP2 CTNNA1 CYP4F2 DACH1 DAXX DCTD DDX21 DDX24 DDX39A DDX39B DDX5 DES DHX9 DMC1 DNM1 DNMT3A DNMT3B DPPA2 DPYSL2 DRG1 DTX3L DZIP3 EDARADD EDF1 EGR2 EIF2AK2 EIF2B1 ELK1 EP300 ERCC6 ESR1 ETS1 ETV1 ETV6 EXO1 EXOSC9 FADD FAF1 FAM118A FANCM FAS FATE1 FHIT FHL3 FLI1 FMR1 FOS FOXL2 FOXM1 GCM1 GIPC2 GLUL GMCL1 GMCL2 GMEB1 GMEB2 GOLGA1 GOLGA2 GOLGB1 GRIP1 GTF2I H4-16 HABP4 HDAC1 HDAC4 HDAC5 HDAC7 HGS HIC1 HIF1A HIPK1 HIPK2 HIPK3 HIRA HMBOX1 HMGB1 HMGN2 HMGXB4 HNF4A HNRNPC HNRNPCL1 HNRNPD HNRNPK HNRNPLL HNRNPM HNRNPU HSF1 HSF2 HSF2BP IKBKG IKZF1 IKZF3 IKZF5 IMPDH1 IPO13 IQGAP1 JUN JUNB KAT2A KAT6B KCNA5 KCNK1 KCTD1 KDM1A KHSRP KLF3 KLF5 KLHL12 KLHL2 KMT5A KRT19 KRTAP5-2 KRTAP5-4 KRTAP5-9 KTN1 LATS1 LCE1D LCE1F LCE2C LCE3B LCE5A LMNA LMNB1 LMO2 LNX2 LONRF1 LRSAM1 MALL MAP2K1 MAP3K1 MAP3K5 MAPK1IP1L MARCHF5 MAT2A MATR3 MDM2 MECOM MED7 MEF2C MGRN1 MIPOL1 MITF MKRN3 MLX MRTFA MTA1 MYB MYBBP1A MYH9 NACC1 NAF1 NAT10 NCOR2 NFKBIA NIN NMI NOL6 NONO NOP2 NOP56 NOP58 NOX5 NR1D2 NR1H2 NR1H3 NR1I2 NR3C1 NR3C2 NR5A1 NR5A2 NSD3 NUDCD3 NVL PAICS PARK7 PARP1 PAX5 PCNA PDLIM7 PDPK1 PDZK1 PELI1 PEX10 PHC1 PIAS1 PIAS2 PIAS3 PIAS4 PIM1 PLAAT4 PLAGL1 PML POLR1H POU1F1 POU2F1 PPARA PPARG PPARGC1A PPCDC PPM1J PRKAA2 PRKDC PROP1 PRPF40A PRPF8 PRPSAP1 PSMC3 PSMC6 PSME3 PTEN PUF60 RABAC1 RAD18 RAD51 RAD52 RAD54B RAD54L2 RANBP2 RANGAP1 RB1 RBBP5 RBBP6 RBM14 RBM25 RC3H2 RCBTB2 RFPL3 RHOXF2 RIPK2 RNF10 RNF111 RNF115 RNF128 RNF133 RNF144B RNF151 RNF185 RNF4 RNF40 RORB RPL11 RPL7 RPL8 RPRD1B RPS3A RPS6KA6 RUSF1 RWDD3 RXRA SAE1 SALL1 SART1 SATB1 SCNN1A SEMA6A SEPTIN1 SETBP1 SETDB1 SETX SFPQ SH3KBP1 SIAH1 SIAH2 SIRT1 SKIL SLC2A1 SLC2A4 SLX4 SMAD4 SNAI2 SND1 SNIP1 SNRNP200 SOCS6 SOX10 SOX4 SOX5 SOX6 SOX9 SP100 SP3 SPECC1L SPOP SREBF1 SREBF2 SRF SRSF4 SSRP1 STAT1 STMN2 STX1A STX1B STX2 SUMO1 SUMO1P1 SUMO2 SUMO3 SUPT7L SUZ12 SYMPK TAB2 TAF1 TAF10 TAF12 TAF5 TBL1X TBL1XR1 TBP TCERG1 TCF3 TCF4 TDG TDP2 TERF2 TFAP2A TFAP2B TFAP2C TFCP2 TFG THAP1 THRA THRB TIGD3 TLK2 TNFRSF1A TOP1 TOP2A TOP2B TOPORS TP53 TP63 TP73 TRAF2 TRAF3 TRAF4 TRAF6 TRIM21 TRIM23 TRIM24 TRIM27 TRIM28 TRIM29 TRIM3 TRIM38 TRIM41 TRIM54 TRIM63 TRIM72 TRIP13 TRPS1 TSHZ2 TSN TSNAX TTN TXLNB UBA2 UBE2K UBQLN1 UBQLN2 UBXN1 UCHL1 UNC119 USP25 VENTX VEZF1 VHL WNK1 WT1 WWP2 XBP1 XIAP XRCC1 XRCC5 ZBED1 ZBTB1 ZBTB16 ZBTB2 ZBTB26 ZBTB7A ZBTB8A ZBTB9 ZC3H10 ZCCHC12 ZCCHC7 ZEB2 ZG16 ZIC1 ZMYM2 ZNF106 ZNF24 ZNF408 ZNF446 ZNF451 ZNF618 ZNF646 ZNF837 ZNRD2	35 interacting genes: ADRB2 AKT1 ARAF ATXN1 BAG3 CLTC COPS5 CSDE1 E2F3 FHL3 FLNC GLIS2 KLHL2 MAP2K1 MAP3K2 MAP3K3 MT-ATP8 PFKP PRKAR1A PRKAR1B PVR RANBP9 SLC9A1 SYT2 TNRC6A TSC22D1 TULP3 UBE2I UPF2 WNK2 YWHAE YWHAG YWHAZ ZNF106 ZYX
Entrez ID		7329	65125
HPRD ID		09045	05570
Ensembl ID		ENSG00000103275	ENSG00000060237
Uniprot IDs		A8K503 B0QYN7 P63279	A5D8Z4 F5GWT4 Q9H4A3
PDB IDs		1A3S 1KPS 1Z5Q 1Z5S 2GRN 2GRO 2GRP 2GRQ 2GRR 2O25 2PE6 2PX9 2XWU 3A4S 3UIN 3UIO 3UIP 4W5V 4Y1L 5D2M 5F6D 5F6E 5F6U 5F6V 5F6W 5F6X 5F6Y 5FQ2 6SYF	4PWN 5TF9 5WDY 5WE8 6FBK
Enriched GO Terms of Interacting Partners?
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