UBE2H and RNF34

Number of citations of the paper that reports this interaction (PubMedID 19549727)
74

Data Source:
BioGRID (two hybrid)

		UBE2H	RNF34
Description		ubiquitin conjugating enzyme E2 H	ring finger protein 34
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Endomembrane System Nuclear Body Nuclear Speck
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Conjugating Enzyme Activity	P53 Binding Protein Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity Phosphatidylinositol Phosphate Binding
	Biological Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Protein Ubiquitination Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Oxygen Metabolic Process Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways		Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation	Regulation of TP53 Degradation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Estimated glomerular filtration rate ( 31152163 31451708) Lymphocyte counts ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Response to antidepressants and depression ( 27622933) White blood cell count ( 32888494)
Interacting Genes		67 interacting genes: BRAP BYSL CBLC CD99 CDK2 DTX3 DTX3L DZIP3 EPS15 GOLGA2 H2AC18 HBP1 HDAC6 JADE1 LNX2 LRSAM1 MAEA MARCHF1 MARCHF10 MARCHF2 MARCHF4 MARCHF8 MKRN3 NEURL1 NHLRC1 POLL POLM PRKN PSME3 RAG1 RELA RNF10 RNF103 RNF113B RNF114 RNF128 RNF133 RNF139 RNF144A RNF146 RNF166 RNF185 RNF186 RNF2 RNF34 RNF38 RNF4 RNF6 STAM2 TLE5 TRAIP TRIM17 TRIM2 TRIM21 TRIM23 TRIM27 TRIM28 TRIM36 TRIM37 TRIM5 TRIM56 TRIM69 UBA1 UBASH3B UBOX5 UBR2 UBR3	11 interacting genes: APP APPBP2 DNAJA3 IKBKG MAVS NOD1 PHF7 TRIM23 UBE2D2 UBE2F UBE2H
Entrez ID		7328	80196
HPRD ID		03052	10509
Ensembl ID		ENSG00000186591	ENSG00000170633
Uniprot IDs		A0A3B3IU20 A4D1L5 P62256	A0A087WTM5 Q969K3
PDB IDs		2Z5D
Enriched GO Terms of Interacting Partners?
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