TSG101 and MGRN1

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology)

		TSG101	MGRN1
Description		tumor susceptibility 101	mahogunin ring finger 1
Image			No pdb structure
GO Annotations	Cellular Component	ESCRT I Complex Nucleolus Cytoplasm Endosome Early Endosome Late Endosome Multivesicular Body Microtubule Organizing Center Cytosol Plasma Membrane Endosome Membrane Early Endosome Membrane Late Endosome Membrane Extracellular Exosome Flemming Body	Nucleus Cytoplasm Early Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	DNA Binding Transcription Corepressor Activity Protein Binding Nuclear Receptor Coactivator Activity Ubiquitin Protein Ligase Binding Protein Homodimerization Activity Ubiquitin Binding Protein-containing Complex Binding Virion Binding Calcium-dependent Protein Binding	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cell Growth Protein Monoubiquitination Extracellular Transport Cell Cycle Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Cell Population Proliferation Endosome To Lysosome Transport Protein Transport Macroautophagy Keratinocyte Differentiation Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Ubiquitin-dependent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of MAP Kinase Activity Positive Regulation Of Transcription, DNA-templated Viral Budding Cell Division Regulation Of Cell Cycle Autophagosome Maturation Regulation Of Viral Release From Host Cell Positive Regulation Of Viral Release From Host Cell Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Positive Regulation Of Viral Budding Via Host ESCRT Complex Exosomal Secretion Positive Regulation Of Ubiquitin-dependent Endocytosis	Protein Polyubiquitination Protein Monoubiquitination Endosome To Lysosome Transport Protein Ubiquitination Negative Regulation Of CAMP-mediated Signaling Negative Regulation Of G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Smoothened Signaling Pathway
Pathways		Budding and maturation of HIV virion Membrane binding and targetting of GAG proteins Endosomal Sorting Complex Required For Transport (ESCRT) HCMV Late Events Late endosomal microautophagy	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Body shape index ( 34021172) HDL cholesterol levels ( 32203549) Hemoglobin ( 32888494) Milk allergy (maternal genetic effects) ( 29489655) Triglyceride levels ( 32154731)
Interacting Genes		122 interacting genes: AATF ADRB2 AJUBA AKAP9 AR ARRDC1 BAG4 BCAS3 BCR BIRC2 CAGE1 CBY1 CCDC88B CCHCR1 CCND3 CDKN1A CDKN2D CDS2 CEP55 CEP63 CNOT7 DAXX DMAP1 DMRTB1 DNMT1 DZIP3 EP300 FAM110A FAM9B GGA1 GGA3 GMCL1 GOLM1 HAUS1 HCK HGS HSH2D INCA1 IQGAP1 ITSN1 JUN KIAA1328 KIF5A KIFC3 KLK5 KLK6 KRT13 KRT15 KRT16 KRT18 KRT31 KRT34 KRT35 KRT75 LCN2 LENG8 LNX1 LRSAM1 MDM2 MGRN1 MKRN3 MTA3 MZB1 NR3C1 OGT PDCD6IP PDLIM7 PIAS1 PKNOX2 PPFIBP2 PPP1R13B PRDM16 PRSS50 QKI RAD18 RASL10B RBPMS RNF111 RNF126 RNF41 ROCK1 SCAMP3 SCARA5 SCGB3A1 SCNN1A SH3GLB2 SHANK3 SNAPIN SNF8 SNX32 STK11 SYCE1 TAX1BP1 TEX11 TFF1 TFIP11 THRB THRSP TNIP1 TNIP2 TNNT3 TOM1L1 TP53 TRAIP TRIM23 TRIM35 TRIM46 TRIM54 TRIM74 TRIML2 UBA52 UBC USHBP1 VPS11 VPS28 VPS36 VPS37A VPS37B VPS37C VPS37D WASHC1 ZWINT	13 interacting genes: AMFR TRIM74 TSG101 UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2G2 UBE2I UBE2J2 UBE2T UBE2W
Entrez ID		7251	23295
HPRD ID		03229	07397
Ensembl ID		ENSG00000074319	ENSG00000102858
Uniprot IDs		Q99816	O60291
PDB IDs		1KPP 1KPQ 1M4P 1M4Q 1S1Q 2F0R 3IV1 3OBQ 3OBS 3OBU 3OBX 3P9G 3P9H 4EJE 4YC1 4ZNY 5VKG 6VME
Enriched GO Terms of Interacting Partners?
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