TRAF6 and UBE2D3

Number of citations of the paper that reports this interaction (PubMedID 19675569)
240

Data Source:
BioGRID (pull down, pull down, enzymatic study, pull down)

		TRAF6	UBE2D3
Description		TNF receptor associated factor 6	ubiquitin conjugating enzyme E2 D3
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GO Annotations	Cellular Component	Nucleus Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cell Cortex Cytoplasmic Side Of Plasma Membrane Endosome Membrane Protein-containing Complex CD40 Receptor Complex Perinuclear Region Of Cytoplasm Plasma Membrane Signaling Receptor Complex	Nucleus Nucleoplasm Cytosol Plasma Membrane Endosome Membrane Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Tumor Necrosis Factor Receptor Binding Protein Binding Zinc Ion Binding Protein Kinase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Ubiquitin Conjugating Enzyme Binding Ubiquitin Protein Ligase Binding Thioesterase Binding Tumor Necrosis Factor Receptor Superfamily Binding Identical Protein Binding Histone Deacetylase Binding Protein Kinase B Binding Protein N-terminus Binding Ubiquitin Protein Ligase Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ossification In Utero Embryonic Development Neural Tube Closure Stimulatory C-type Lectin Receptor Signaling Pathway Regulation Of Immunoglobulin Production Positive Regulation Of T Cell Cytokine Production Cytoplasmic Pattern Recognition Receptor Signaling Pathway MyD88-dependent Toll-like Receptor Signaling Pathway Cellular Response To DNA Damage Stimulus I-kappaB Kinase/NF-kappaB Signaling Activation Of NF-kappaB-inducing Kinase Activity JNK Cascade Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Osteoclast Differentiation Positive Regulation Of Protein Ubiquitination Positive Regulation Of Lipopolysaccharide-mediated Signaling Pathway Activation Of Protein Kinase Activity Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-6 Production Tumor Necrosis Factor-mediated Signaling Pathway Fc-epsilon Receptor Signaling Pathway T-helper 1 Type Immune Response Positive Regulation Of T Cell Proliferation Odontogenesis Of Dentin-containing Tooth Regulation Of Apoptotic Process Myeloid Dendritic Cell Differentiation Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of JUN Kinase Activity Bone Resorption Positive Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Cell Development Positive Regulation Of Smooth Muscle Cell Proliferation T Cell Receptor Signaling Pathway Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Interleukin-1-mediated Signaling Pathway Protein K63-linked Ubiquitination Response To Interleukin-1 Cellular Response To Lipopolysaccharide Cellular Response To Cytokine Stimulus Interleukin-17-mediated Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Transcription Regulatory Region DNA Binding	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination DNA Repair Cellular Protein Modification Process Protein Monoubiquitination Apoptotic Process Protein Ubiquitination Negative Regulation Of BMP Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Response To Cadmium Ion Cellular Response To Mercury Ion Positive Regulation Of Protein Targeting To Mitochondrion
Pathways		PIP3 activates AKT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane NOD1/2 Signaling Pathway TICAM1, RIP1-mediated IKK complex recruitment Regulated proteolysis of p75NTR Downstream TCR signaling NRIF signals cell death from the nucleus NRIF signals cell death from the nucleus p75NTR recruits signalling complexes NF-kB is activated and signals survival FCERI mediated NF-kB activation TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 CLEC7A (Dectin-1) signaling Ub-specific processing proteases Ovarian tumor domain proteases PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling TICAM1,TRAF6-dependent induction of TAK1 complex Interleukin-1 signaling TRAF6 mediated IRF7 activation TRAF6 mediated NF-kB activation TRAF6 mediated NF-kB activation IRAK1 recruits IKK complex IKK complex recruitment mediated by RIP1 IRAK2 mediated activation of TAK1 complex TRAF6-mediated induction of TAK1 complex within TLR4 complex Alpha-protein kinase 1 signaling pathway TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation MyD88 dependent cascade initiated on endosome IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation MyD88 cascade initiated on plasma membrane	Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Idiopathic inflammatory myopathy ( 26362759) Metabolite levels ( 23823483) Rheumatoid arthritis ( 30423114 24390342)	Alanine aminotransferase levels ( 33547301) Asthma and attention deficit hyperactivity disorder ( 31619474) Diastolic blood pressure ( 30224653) Fasting glucose ( 33402679) Shoulder impingement or rotator cuff tear ( 33482370)
Interacting Genes		187 interacting genes: ABL1 APP ARFGAP2 ATM ATP6V1E1 ATXN3 BANK1 BCL3 BEX3 BMPR1B BRSK2 C1GALT1 CALCOCO2 CASP8 CAV1 CBL CD40 CUL5 CYLD DLG4 DNA2 ECSIT EDA2R EDARADD EHF F2 FHL2 FYN GART GSK3B GTF2I H2AX H2BC21 HNRNPA1 HSD17B10 HSPA4 IFTAP IL17RB IPMK IQUB IRAK1 IRAK2 IRAK3 IRAK4 IRF5 IRF7 IRF8 JAK2 KCNQ1 LIMD1 LNX1 LRRC4C MALT1 MAP2K1 MAP2K6 MAP2K7 MAP3K11 MAP3K14 MAP3K3 MAP3K5 MAP3K7 MAP3K8 MAPK14 MAPK8 MAPT MAST2 MATR3 MAVS MBP MCL1 MEOX2 MTOR MTURN NEAT1 NGFR NOL3 NTRK1 NTRK2 NTSR1 NUMBL OTUB1 OTUB2 OTUD7B PEDS1-UBE2V1 PELI3 PFN1 PHLDA1 PINK1 PLEKHF2 PLEKHO1 POLI PPP4C PRKCZ PSMB5 PSMC1 PSMC2 PSMC3 PSMD1 PSMD12 PSMD13 PSMD6 PSMD7 PTPN6 RAD23A RIPK2 RNF114 RNF152 RNF31 RPL3 RPP21 RPS2 RPS20 RPS27A SIGIRR SPHK1 SPOP SQSTM1 SRC STAMBP STK17A STK26 STRADB STUB1 SYK TAB1 TAB2 TAB3 TANK TAX1BP1 TDP2 TGFBR1 TICAM1 TICAM2 TIFA TIMM8A TIRAP TLR3 TNFAIP3 TNFRSF11A TNFRSF13B TNFRSF19 TNFSF11 TRAF1 TRAF2 TRAF3IP1 TRAF3IP2 TRAF4 TRAF5 TRAF7 TRAFD1 TRAM1 TRIM17 TRIM25 TRIM37 TXNIP UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2I UBE2L3 UBE2N UBE2V1 UBOX5 UBTD1 UBXN7 UEVLD USP1 USP15 USP2 USP21 USP39 USP7 VPS52 XIAP YBX1 YES1 YOD1 YWHAQ ZBTB25 ZFAND5 ZMYND11 ZNF675 ZRANB1	212 interacting genes: AMBRA1 AMFR ANAPC11 AREL1 ARIH1 ARIH2 ATXN3 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BMI1 BRCA1 CADPS2 CBL CBLC CHFR CNOT4 CSNK2A1 CUL2 CUL4B DBN1 DCAF1 DCUN1D1 DDX58 DTX1 DTX2 DTX3 DTX3L DZIP3 EPS15 F12 FBXL12 FBXL2 FBXO2 FBXO25 FBXO7 FBXW11 FBXW8 FOCAD FZR1 HDAC6 HECTD1 HECW1 HECW2 HERC1 HERC2 HSP90AB1 HSPA1A HUWE1 IKBKG ITCH KAT2B KDM1B LRSAM1 MAEA MAP3K1 MAPT MARCHF3 MARCHF5 MARCHF7 MARCHF8 MDM2 MDM4 MEX3B MEX3C MGRN1 MIB1 MID1 MID2 MKRN1 MKRN3 MSL1 MSL2 MUL1 MYCBP2 MYLIP NBR1 NEDD4 NEDD4L NFKB1 NFKBIA NHLRC1 NOSIP PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PCNA PDCD5 PELI1 PJA1 PJA2 POLL POLM PRPF19 RABGEF1 RBCK1 RBX1 RCHY1 RELA RFFL RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF111 RNF114 RNF115 RNF122 RNF125 RNF126 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF168 RNF181 RNF185 RNF19B RNF2 RNF213 RNF216 RNF220 RNF25 RNF26 RNF31 RNF38 RNF4 RNF41 RNF43 RNF5 RNF8 RNFT1 RPLP1 RSPRY1 SAT1 SH3RF1 SIAH1 SIAH2 SMURF1 SMURF2 SQSTM1 STAM2 STAU1 STK25 STUB1 SYVN1 TMEM129 TOPORS TRAF6 TRAIP TRIM10 TRIM17 TRIM2 TRIM23 TRIM26 TRIM27 TRIM28 TRIM31 TRIM32 TRIM33 TRIM35 TRIM37 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM55 TRIM58 TRIM62 TRIM63 TRIM68 TRIM69 TRIM7 TRIM8 TUBA1A UBA1 UBA6 UBASH3B UBC UBE2O UBE3A UBE3C UBE4A UBE4B UBOX5 UBR5 UFM1 UHRF1 USP7 UVSSA VHL WSB1 WWP1 WWP2 XIAP XPNPEP1 ZNRF1 ZNRF2 ZNRF4
Entrez ID		7189	7323
HPRD ID		03833	04269
Ensembl ID		ENSG00000175104	ENSG00000109332
Uniprot IDs		Q9Y4K3	A0A024RDH2 D6RAH7 P61077
PDB IDs		1LB4 1LB5 1LB6 2ECI 2JMD 3HCS 3HCT 3HCU 4Z8M 5ZUJ 6A33 7L3L	1X23 2FUH 3L1Z 3RPG 3UGB 4BVU 4R8P 4S3O 5EGG 5IFR 6CP0 6T7F 7JZV
Enriched GO Terms of Interacting Partners?
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