UBE2D3 and SMURF2

Number of citations of the paper that reports this interaction (PubMedID 30021006)
6

Data Source:
BioGRID (pull down)

		UBE2D3	SMURF2
Description		ubiquitin conjugating enzyme E2 D3	SMAD specific E3 ubiquitin protein ligase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Endosome Membrane Extracellular Exosome	Ubiquitin Ligase Complex Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Nuclear Speck Membrane Raft
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity	Ubiquitin-protein Transferase Activity Transforming Growth Factor Beta Receptor Binding Protein Binding Identical Protein Binding SMAD Binding Ubiquitin Protein Ligase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination DNA Repair Cellular Protein Modification Process Protein Monoubiquitination Apoptotic Process Protein Ubiquitination Negative Regulation Of BMP Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein Autoubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Cellular Response To Cadmium Ion Cellular Response To Mercury Ion Positive Regulation Of Protein Targeting To Mitochondrion	Negative Regulation Of Transcription By RNA Polymerase II Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Negative Regulation Of BMP Signaling Pathway Ubiquitin-dependent SMAD Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Negative Regulation Of Transcription, DNA-templated Wnt Signaling Pathway, Planar Cell Polarity Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Trophoblast Cell Migration
Pathways		Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha TICAM1, RIP1-mediated IKK complex recruitment Signaling by BMP Downregulation of SMAD2/3:SMAD4 transcriptional activity E3 ubiquitin ligases ubiquitinate target proteins Neddylation Peroxisomal protein import Negative regulators of DDX58/IFIH1 signaling IKK complex recruitment mediated by RIP1 Inactivation of CSF3 (G-CSF) signaling Antigen processing: Ubiquitination & Proteasome degradation	Signaling by BMP Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Asymmetric localization of PCP proteins Degradation of AXIN Hedgehog 'on' state Hedgehog 'on' state Ub-specific processing proteases Regulation of RUNX3 expression and activity Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Alanine aminotransferase levels ( 33547301) Asthma and attention deficit hyperactivity disorder ( 31619474) Diastolic blood pressure ( 30224653) Fasting glucose ( 33402679) Shoulder impingement or rotator cuff tear ( 33482370)	Cardiac troponin-I levels ( 31014085) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Joint mobility (Beighton score) ( 27182965) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Periodontitis (Mean PAL) ( 24024966)
Interacting Genes		212 interacting genes: AMBRA1 AMFR ANAPC11 AREL1 ARIH1 ARIH2 ATXN3 BARD1 BFAR BIRC2 BIRC3 BIRC7 BIRC8 BMI1 BRCA1 CADPS2 CBL CBLC CHFR CNOT4 CSNK2A1 CUL2 CUL4B DBN1 DCAF1 DCUN1D1 DDX58 DTX1 DTX2 DTX3 DTX3L DZIP3 EPS15 F12 FBXL12 FBXL2 FBXO2 FBXO25 FBXO7 FBXW11 FBXW8 FOCAD FZR1 HDAC6 HECTD1 HECW1 HECW2 HERC1 HERC2 HSP90AB1 HSPA1A HUWE1 IKBKG ITCH KAT2B KDM1B LRSAM1 MAEA MAP3K1 MAPT MARCHF3 MARCHF5 MARCHF7 MARCHF8 MDM2 MDM4 MEX3B MEX3C MGRN1 MIB1 MID1 MID2 MKRN1 MKRN3 MSL1 MSL2 MUL1 MYCBP2 MYLIP NBR1 NEDD4 NEDD4L NFKB1 NFKBIA NHLRC1 NOSIP PCGF1 PCGF2 PCGF3 PCGF5 PCGF6 PCNA PDCD5 PELI1 PJA1 PJA2 POLL POLM PRPF19 RABGEF1 RBCK1 RBX1 RCHY1 RELA RFFL RFWD3 RING1 RLIM RMND5B RNF10 RNF103 RNF111 RNF114 RNF115 RNF122 RNF125 RNF126 RNF13 RNF130 RNF14 RNF150 RNF165 RNF166 RNF167 RNF168 RNF181 RNF185 RNF19B RNF2 RNF213 RNF216 RNF220 RNF25 RNF26 RNF31 RNF38 RNF4 RNF41 RNF43 RNF5 RNF8 RNFT1 RPLP1 RSPRY1 SAT1 SH3RF1 SIAH1 SIAH2 SMURF1 SMURF2 SQSTM1 STAM2 STAU1 STK25 STUB1 SYVN1 TMEM129 TOPORS TRAF6 TRAIP TRIM10 TRIM17 TRIM2 TRIM23 TRIM26 TRIM27 TRIM28 TRIM31 TRIM32 TRIM33 TRIM35 TRIM37 TRIM38 TRIM39 TRIM43 TRIM45 TRIM5 TRIM50 TRIM54 TRIM55 TRIM58 TRIM62 TRIM63 TRIM68 TRIM69 TRIM7 TRIM8 TUBA1A UBA1 UBA6 UBASH3B UBC UBE2O UBE3A UBE3C UBE4A UBE4B UBOX5 UBR5 UFM1 UHRF1 USP7 UVSSA VHL WSB1 WWP1 WWP2 XIAP XPNPEP1 ZNRF1 ZNRF2 ZNRF4	91 interacting genes: ABRAXAS2 ACBD3 ACOX3 AIMP2 ANAPC5 ARHGAP5 ASH2L AXIN1 BTRC CANX CNKSR2 CUEDC1 DAB2 DAZAP2 DGCR2 EGFR EPHA1 FKBP4 FLNB FOXJ1 FUBP1 GNG2 HDGFL3 ING2 IRF3 IRF8 ITGB1BP1 KLF5 LAPTM5 LATS1 LMNA MAVS NEK6 NKIRAS1 NRAS PDE4B PPID PRICKLE1 PRICKLE2 RAB13 RAB14 RAB17 RAB22A RAB25 RAN RAP1B RASD2 RASL12 RHOA RHOD RLIM RNF11 RNF111 RNF2 RPS27A RRAS2 RTN4IP1 RUNX2 RUNX3 SF3A2 SIRT1 SKIL SMAD1 SMAD2 SMAD3 SMAD5 SMAD6 SMAD7 SMAP1 SNCA SNRNP70 SOCS6 SPART SRSF4 TFPI2 TGFBR1 TMEM139 TNPO3 TOP2A TRAF2 TRAF4 TSSK4 TXNIP UBC UBE2D2 UBE2D3 UBE2L3 USP15 XPO1 YY1 ZBTB44
Entrez ID		7323	64750
HPRD ID		04269	06901
Ensembl ID		ENSG00000109332	ENSG00000108854
Uniprot IDs		A0A024RDH2 D6RAH7 P61077	Q96DE7 Q9HAU4
PDB IDs		1X23 2FUH 3L1Z 3RPG 3UGB 4BVU 4R8P 4S3O 5EGG 5IFR 6CP0 6T7F 7JZV	1ZVD 2DJY 2JQZ 2KXQ 2LTZ 6FX4
Enriched GO Terms of Interacting Partners?
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