TPSAB1 and ADAMTS1

		TPSAB1	ADAMTS1
Description		tryptase alpha/beta 1	ADAM metallopeptidase with thrombospondin type 1 motif 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space Collagen-containing Extracellular Matrix	Extracellular Region Basement Membrane Extracellular Matrix Cytoplasmic Vesicle Collagen-containing Extracellular Matrix
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Identical Protein Binding	Metalloendopeptidase Activity Protein Binding Heparin Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Proteolysis Defense Response Extracellular Matrix Disassembly	Ovulation From Ovarian Follicle Kidney Development Proteolysis Integrin-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Extracellular Matrix Organization Heart Trabecula Formation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Activation of Matrix Metalloproteinases	Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs		Amido Phenyl Pyruvic Acid 4-PIPERIDIN-4-YLBUTANAL [4-(3-AMINOMETHYL-PHENYL)-PIPERIDIN-1-YL]-(5-PHENETHYL- PYRIDIN-3-YL)-METHANONE 1-(1'-{[3-(methylsulfanyl)-2-benzothiophen-1-yl]carbonyl}spiro[1-benzofuran-3,4'-piperidin]-5-yl)methanamine 1-[1'-(3-phenylacryloyl)spiro[1-benzofuran-3,4'-piperidin]-5-yl]methanamine JNJ-27390467
Diseases
GWAS		Blood protein levels ( 30072576 29875488 28240269)	Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or family history of Alzheimer's disease ( 33589840) Blood protein levels ( 28240269) Cerebrospinal fluid neurofilament light levels ( 31930058) Health literacy ( 31250787) Metabolite levels ( 23823483)
Interacting Genes		2 interacting genes: ADAMTS1 HSP90AB1	11 interacting genes: A2M ACAN ADRA2B FAM32A FURIN JAML KRT40 KRTAP10-8 TPSAB1 VCAN VEGFA
Entrez ID		7177	9510
HPRD ID		01849	05530
Ensembl ID		ENSG00000172236	ENSG00000154734
Uniprot IDs		P20231 Q15661	B2RB33 Q9UHI8
PDB IDs		1A0L 1AAO 1LTO 2BM2 2F9N 2F9O 2F9P 2FPZ 2FS8 2FS9 2FWW 2FXR 2GDD 2ZA5 2ZEB 2ZEC 3V7T 4A6L 4MPU 4MPV 4MPW 4MPX 4MQA 5F03 5WI6 6O1F 6P0P 6VVU	2JIH 2V4B 3Q2G 3Q2H
Enriched GO Terms of Interacting Partners?
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