ADAMTS1

Description		ADAM metallopeptidase with thrombospondin type 1 motif 1
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GO Annotations	Cellular Component	Extracellular Region Basement Membrane Extracellular Matrix Cytoplasmic Vesicle Collagen-containing Extracellular Matrix
	Molecular Function	Metalloendopeptidase Activity Protein Binding Heparin Binding Metallopeptidase Activity Zinc Ion Binding
	Biological Process	Ovulation From Ovarian Follicle Kidney Development Proteolysis Integrin-mediated Signaling Pathway Negative Regulation Of Cell Population Proliferation Negative Regulation Of Angiogenesis Extracellular Matrix Organization Heart Trabecula Formation Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Degradation of the extracellular matrix Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases
GWAS		Alzheimer's disease (late onset) ( 30820047) Alzheimer's disease or family history of Alzheimer's disease ( 33589840) Blood protein levels ( 28240269) Cerebrospinal fluid neurofilament light levels ( 31930058) Health literacy ( 31250787) Metabolite levels ( 23823483)
Interacting Genes		11 interacting genes: A2M ACAN ADRA2B FAM32A FURIN JAML KRT40 KRTAP10-8 TPSAB1 VCAN VEGFA
Entrez ID		9510
HPRD ID		05530
Ensembl ID		ENSG00000154734
Uniprot IDs		B2RB33 Q9UHI8
PDB IDs		2JIH 2V4B 3Q2G 3Q2H
Enriched GO Terms of Interacting Partners?
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