TPM4 and TPM1

Number of citations of the paper that reports this interaction (PubMedID 26186194)
524

Data Source:
BioGRID (two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical)

		TPM4	TPM1
Description		tropomyosin 4	tropomyosin 1
Image		No pdb structure
GO Annotations	Cellular Component	Stress Fiber Podosome Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Focal Adhesion Membrane Cortical Cytoskeleton Extracellular Exosome	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Sarcomere Bleb Ruffle Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding
	Biological Process	Osteoblast Differentiation Muscle Contraction Actin Filament Organization	Positive Regulation Of Heart Rate By Epinephrine Muscle Contraction Regulation Of Muscle Contraction Cytoskeleton Organization Actin Filament Organization Regulation Of Heart Contraction Regulation Of Cell Shape Muscle Filament Sliding Negative Regulation Of Cell Migration Ruffle Organization Positive Regulation Of ATPase Activity Cellular Response To Reactive Oxygen Species Wound Healing Sarcomere Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration
Pathways		Striated Muscle Contraction Smooth Muscle Contraction RHOV GTPase cycle Signaling by ALK fusions and activated point mutants	Striated Muscle Contraction Smooth Muscle Contraction
Drugs		Phenethyl Isothiocyanate	Artenimol Phenethyl Isothiocyanate
Diseases
GWAS		Longevity ( 33657282) Mean platelet volume ( 31080455 22139419 32888494 22423221 27863252) Platelet count ( 26805783 22139419 32888494 22423221 27863252) Platelet distribution width ( 32888494 27863252) Plateletcrit ( 32888494 27863252)	Apolipoprotein A1 levels ( 32203549) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31451708) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin ( 32888494) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Mean platelet volume ( 19820697 32888494 27863252) Orofacial clefts ( 22863734) Parkinson's disease ( 32201043) Parkinson's disease (familial, age at onset) ( 27402877) Platelet count ( 22139419 32888494 27863252) Platelet distribution width ( 32888494 27863252) Pulse pressure ( 27841878) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549)
Interacting Genes		14 interacting genes: DANCR JRK LNX1 NOD2 PACSIN1 PICK1 PRKACA RAB8A SMURF1 SNAPIN TCERG1 TPM1 TPM3 TRIP6	33 interacting genes: ACTB BLOC1S6 C1orf216 CAGE1 CCDC96 CCHCR1 CDC42 CLIP4 EGFR EPB41 FAM9C FGA GOLGA2 IFIT3 JUN KXD1 MAD1L1 MAST2 NEB NOD2 PKD2 PSMC5 S100A2 SNAPIN SYCE1 TFPT TMOD2 TNNT1 TNNT2 TPM2 TPM4 WASHC1 YEATS4
Entrez ID		7171	7168
HPRD ID		11734	01839
Ensembl ID		ENSG00000167460	ENSG00000140416
Uniprot IDs		A0A5F9UN72 K7ENT6 P67936 V9HW56	A0A024R5W6 A0A0K0K1I0 B7Z596 B7Z722 D9YZV4 D9YZV5 D9YZV7 F5H7S3 H0YK48 H7BYY1 O15513 P09493
PDB IDs			3MUD 5KHT 6UT2 6X5Z
Enriched GO Terms of Interacting Partners?
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