TPM1 and NOD2

Number of citations of the paper that reports this interaction (PubMedID 27812135)
4

Data Source:
BioGRID (two hybrid)

		TPM1	NOD2
Description		tropomyosin 1	nucleotide binding oligomerization domain containing 2
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Cytosol Cytoskeleton Muscle Thin Filament Tropomyosin Actin Filament Actin Cytoskeleton Sarcomere Bleb Ruffle Membrane	Cytoplasm Mitochondrion Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Cell Surface Basolateral Plasma Membrane Vesicle Protein-containing Complex Phagocytic Vesicle Anchored Component Of Plasma Membrane
	Molecular Function	Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Actin Filament Binding	Actin Binding Protein Binding ATP Binding Enzyme Binding Protein Kinase Binding Hsp70 Protein Binding Muramyl Dipeptide Binding Pattern Recognition Receptor Activity Peptidoglycan Binding Protein-containing Complex Binding CARD Domain Binding Hsp90 Protein Binding
	Biological Process	Positive Regulation Of Heart Rate By Epinephrine Muscle Contraction Regulation Of Muscle Contraction Cytoskeleton Organization Actin Filament Organization Regulation Of Heart Contraction Regulation Of Cell Shape Muscle Filament Sliding Negative Regulation Of Cell Migration Ruffle Organization Positive Regulation Of ATPase Activity Cellular Response To Reactive Oxygen Species Wound Healing Sarcomere Organization Positive Regulation Of Cell Adhesion Positive Regulation Of Stress Fiber Assembly Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Contraction Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration	Pattern Recognition Receptor Signaling Pathway Innate Immune Response In Mucosa Activation Of Immune Response Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of T Cell Mediated Immunity Positive Regulation Of Cytokine Production Involved In Immune Response Positive Regulation Of Dendritic Cell Cytokine Production Positive Regulation Of Type 2 Immune Response Negative Regulation Of Inflammatory Response To Antigenic Stimulus Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Defense Response Positive Regulation Of Biosynthetic Process Of Antibacterial Peptides Active Against Gram-positive Bacteria Response To Nutrient Detection Of Biotic Stimulus Detection Of Bacterium Maintenance Of Gastrointestinal Epithelium Negative Regulation Of NF-kappaB Transcription Factor Activity Response To Muramyl Dipeptide Detection Of Muramyl Dipeptide Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-18 Production Negative Regulation Of Interleukin-2 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Intracellular Signal Transduction Defense Response To Bacterium Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Response To Exogenous DsRNA Positive Regulation Of MAP Kinase Activity Positive Regulation Of Phosphatidylinositol 3-kinase Activity Innate Immune Response Positive Regulation Of Innate Immune Response Positive Regulation Of Notch Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Gamma-delta T Cell Activation Positive Regulation Of Epithelial Cell Proliferation Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Phagocytosis Defense Response To Gram-positive Bacterium Positive Regulation Of B Cell Activation Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Oxidoreductase Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity Positive Regulation Of ERK1 And ERK2 Cascade Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Peptidoglycan Cellular Response To Muramyl Dipeptide Cellular Response To Organic Cyclic Compound Positive Regulation Of Monocyte Chemotactic Protein-1 Production Regulation Of Neutrophil Chemotaxis Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Protein K63-linked Ubiquitination Positive Regulation Of Xenophagy Negative Regulation Of Macrophage Apoptotic Process Positive Regulation Of Prostaglandin-E Synthase Activity
Pathways		Striated Muscle Contraction Smooth Muscle Contraction	NOD1/2 Signaling Pathway NOD1/2 Signaling Pathway TAK1 activates NFkB by phosphorylation and activation of IKKs complex activated TAK1 mediates p38 MAPK activation JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Ovarian tumor domain proteases Interleukin-1 signaling
Drugs		Artenimol Phenethyl Isothiocyanate	Mifamurtide
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31451708) HDL cholesterol levels ( 32203549) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin ( 32888494) Impaired insulin sensitivity in response to n-3 PUFA supplementation ( 31779001) Mean platelet volume ( 19820697 32888494 27863252) Orofacial clefts ( 22863734) Parkinson's disease ( 32201043) Parkinson's disease (familial, age at onset) ( 27402877) Platelet count ( 22139419 32888494 27863252) Platelet distribution width ( 32888494 27863252) Pulse pressure ( 27841878) Refractive error ( 32231278) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549)	Asthma ( 31361310 30929738 32296059) Asthma (childhood onset) ( 31036433 30929738) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 18587394 28067908 20570966 22936669 22412388 17554300 21102463 23128233 17804789) Inflammatory bowel disease ( 18758464 28067908) Leprosy ( 20018961 27976721 25642632) Medication use (thyroid preparations) ( 31015401) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Pediatric autoimmune diseases ( 26301688)
Interacting Genes		33 interacting genes: ACTB BLOC1S6 C1orf216 CAGE1 CCDC96 CCHCR1 CDC42 CLIP4 EGFR EPB41 FAM9C FGA GOLGA2 IFIT3 JUN KXD1 MAD1L1 MAST2 NEB NOD2 PKD2 PSMC5 S100A2 SNAPIN SYCE1 TFPT TMOD2 TNNT1 TNNT2 TPM2 TPM4 WASHC1 YEATS4	40 interacting genes: ALPI ANKHD1 ANXA2 ATG16L1 C10orf67 CCL13 CHMP4B CHMP5 CNOT1 DCTN1 DOCK7 ENTR1 ERBIN GOLGA6L5P GOLGB1 HAP1 IKBIP IRGM LDOC1 LMNA LURAP1L MAP3K7 NLRC4 PDLIM5 PPP1R12C PPP2R3B PRR16 RIPK2 RPL13A SCYL1 SETD6 TACC3 TNIP1 TPM1 TPM3 TPM4 TRIM41 VCP WBP11 XIAP
Entrez ID		7168	64127
HPRD ID		01839	05810
Ensembl ID		ENSG00000140416	ENSG00000167207
Uniprot IDs		A0A024R5W6 A0A0K0K1I0 B7Z596 B7Z722 D9YZV4 D9YZV5 D9YZV7 F5H7S3 H0YK48 H7BYY1 O15513 P09493	A0A286YF65 Q9HC29
PDB IDs		3MUD 5KHT 6UT2 6X5Z
Enriched GO Terms of Interacting Partners?
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