TNNI2 and HNF4G

Number of citations of the paper that reports this interaction (PubMedID 15604093)
56

Data Source:
BioGRID (two hybrid)

		TNNI2	HNF4G
Description		troponin I2, fast skeletal type	hepatocyte nuclear factor 4 gamma
Image
GO Annotations	Cellular Component	Nucleus Cytosol Troponin Complex	Chromatin Nucleoplasm Cytosol Intercellular Bridge Mitotic Spindle
	Molecular Function	Actin Binding Protein Binding Troponin T Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Nuclear Receptor Activity Zinc Ion Binding
	Biological Process	Skeletal Muscle Contraction Muscle Contraction Regulation Of Muscle Contraction Positive Regulation Of Transcription, DNA-templated Cardiac Muscle Contraction	Regulation Of Transcription By RNA Polymerase II Cell Differentiation Intracellular Receptor Signaling Pathway Positive Regulation Of Transcription By RNA Polymerase II Anatomical Structure Development
Pathways		Striated Muscle Contraction	Regulation of gene expression in beta cells Nuclear Receptor transcription pathway
Drugs			Palmitic Acid
Diseases
GWAS		Celiac disease ( 23936387) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Inflammatory bowel disease ( 23128233) Logical memory (delayed recall) in mild cognitive impairment ( 29274321) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)	Adult body size ( 32376654) Attention function ( 29907492) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 26426971 28892062 25673413 20935630 28448500) Body mass index (age <50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Breast cancer ( 29059683 23535729) Chronotype ( 30696823) Estimated glomerular filtration rate ( 31152163) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Morning person ( 30696823) Number of sexual partners ( 30643258) Obesity ( 23563607) Pancreatic cancer ( 29422604) Pulse pressure ( 27841878) Red blood cell count ( 32888494) Serum uric acid levels ( 30993211 29403010) Systolic blood pressure ( 27841878) Urate levels ( 31985003 31578528 23263486) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		22 interacting genes: ACTB C1orf109 CALM1 CTNNA3 DCAF11 EFCAB2 ESRRA ESRRG HNF4G MNS1 NME7 PKD2L1 PSMC5 RORB TH TNNC1 TNNC2 TNNT1 TNNT3 TRIM55 TRIM63 UPF2	16 interacting genes: COPS5 DNMT3L ELOC GAPDH HAX1 HLF NCOA1 NR0B2 NSD1 PNRC1 PNRC2 PRDX6 PSMC5 RANBP9 TNNI2 ZNF629
Entrez ID		7136	3174
HPRD ID		01843	06909
Ensembl ID		ENSG00000130598	ENSG00000164749
Uniprot IDs		P48788	F1D8Q4 Q14541
PDB IDs		2MKP	1LV2
Enriched GO Terms of Interacting Partners?
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