TDO2 and DPM1

Number of citations of the paper that reports this interaction (PubMedID 25910212)
170

Data Source:
BioGRID (two hybrid)

		TDO2	DPM1
Description		tryptophan 2,3-dioxygenase	dolichyl-phosphate mannosyltransferase subunit 1, catalytic
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane Dolichol-phosphate-mannose Synthase Complex
	Molecular Function	Tryptophan 2,3-dioxygenase Activity Protein Binding Amino Acid Binding Oxygen Binding Heme Binding Identical Protein Binding Metal Ion Binding	Dolichyl-phosphate-mannose-protein Mannosyltransferase Activity Dolichyl-phosphate Beta-D-mannosyltransferase Activity Protein Binding Mannose Binding Alcohol Binding
	Biological Process	Tryptophan Catabolic Process To Kynurenine Tryptophan Catabolic Process To Acetyl-CoA Protein Homotetramerization Response To Nitroglycerin	GPI Anchor Biosynthetic Process Dolichol Metabolic Process GDP-mannose Metabolic Process Protein Mannosylation Protein O-linked Mannosylation
Pathways		Tryptophan catabolism	Synthesis of dolichyl-phosphate mannose Defective DPM1 causes DPM1-CDG (CDG-1e) Defective DPM3 causes DPM3-CDG (CDG-1o) Defective DPM2 causes DPM2-CDG (CDG-1u)
Drugs
Diseases
GWAS		Blood metabolite levels ( 24816252) Manganese levels ( 26025379) Speech perception in dyslexia ( 19786962)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)
Interacting Genes		20 interacting genes: ASMTL DPM1 EIF4E KDM1A LMNA LNX1 MEOX2 MOB1A MOB3C NGB NMNAT1 NR1D1 PICK1 PM20D2 PRMT6 PSMA1 REL SDCBP SDCBP2 ZFYVE26	7 interacting genes: DPM2 DPM3 MEOX2 MTNR1A PTEN TDO2 ZBTB16
Entrez ID		6999	8813
HPRD ID		01847	04613
Ensembl ID		ENSG00000151790	ENSG00000000419
Uniprot IDs		P48775	A0A0S2Z4Y5 O60762 Q5QPK2
PDB IDs		4PW8 5TI9 5TIA 6A4I 6PYY 6PYZ 6UD5 6VBN
Enriched GO Terms of Interacting Partners?
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