TRIM21 and RO60

Number of citations of the paper that reports this interaction (PubMedID 11251884)
2

Data Source:
HPRD (in vivo)

		TRIM21	RO60
Description		tripartite motif containing 21	Ro60, Y RNA binding protein
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Cytoplasmic Vesicle Ribonucleoprotein Complex	Nucleoplasm Cytosol Ribonucleoprotein Complex
	Molecular Function	DNA Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	RNA Binding U2 SnRNA Binding Metal Ion Binding
	Biological Process	Protein Polyubiquitination Protein Monoubiquitination Cell Cycle Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Regulation Of Protein Localization Negative Regulation Of Viral Transcription Response To Interferon-gamma Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Cell Cycle Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Protein K63-linked Ubiquitination Negative Regulation Of Protein Deubiquitination Negative Regulation Of Viral Release From Host Cell	Immune System Development Transcription By RNA Polymerase III Smoothened Signaling Pathway Response To UV Regulation Of Gene Expression Cellular Response To Interferon-alpha Cilium Assembly
Pathways		STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA Interferon gamma signaling Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Lung cancer ( 28604730) Malaria ( 31844061)
Interacting Genes		70 interacting genes: ALOX15B APC CALR CASP8AP2 CBX4 CDC34 CUL1 CWC25 DAXX DCP2 DMAP1 DZIP3 EHHADH ELAVL1 EXOC8 FADD FBXW11 FHOD1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GRAP HLA-DRB1 IGFN1 IGHG1 IGHV4-31 IKBKB IRF5 IRF8 LNX1 MAP1LC3A MAP1LC3B MAP1LC3C MNAT1 NIF3L1 PFKP RBCK1 RNF111 RO60 SAMHD1 SETD7 SKP2 SQSTM1 TBK1 TCP11L1 TH TNS4 TRIM27 TRIM3 TRIM39 TRIM5 TRIM8 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2E1 UBE2H UBE2I UBE2L3 USP15 USP2 USP4 VPS9D1 XAF1 YJU2 YWHAZ ZBTB16	8 interacting genes: CDC42 DDX6 DSC2 OGT RAB11FIP5 RNY1 RNY3 TRIM21
Entrez ID		6737	6738
HPRD ID		00170	15964
Ensembl ID		ENSG00000132109	ENSG00000116747
Uniprot IDs		P19474	A0A024R983 G5E9R9 P10155
PDB IDs		2IWG 5JPX 5OLM 6FGA 6S53 7BBD
Enriched GO Terms of Interacting Partners?
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