TRIM21 and GRAP

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid, two hybrid)

		TRIM21	GRAP
Description		tripartite motif containing 21	GRB2 related adaptor protein
Image			No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Nucleoplasm Cytoplasm Autophagosome Cytosol Cytoplasmic Vesicle Ribonucleoprotein Complex	Cytoplasm Cytosol Membrane Presynapse
	Molecular Function	DNA Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Protein Polyubiquitination Protein Monoubiquitination Cell Cycle Regulation Of Gene Expression Positive Regulation Of Autophagy Protein Ubiquitination Protein Destabilization Negative Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Protein Binding Regulation Of Type I Interferon Production Regulation Of Protein Localization Negative Regulation Of Viral Transcription Response To Interferon-gamma Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Cell Cycle Negative Regulation Of Innate Immune Response Positive Regulation Of Transcription, DNA-templated Regulation Of Viral Entry Into Host Cell Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Autoubiquitination Protein K63-linked Ubiquitination Negative Regulation Of Protein Deubiquitination Negative Regulation Of Viral Release From Host Cell	Ras Protein Signal Transduction Cell-cell Signaling Sensory Perception Of Sound
Pathways		STING mediated induction of host immune responses Regulation of innate immune responses to cytosolic DNA Interferon gamma signaling Antigen processing: Ubiquitination & Proteasome degradation	Signaling by SCF-KIT
Drugs
Diseases
GWAS		Lung cancer ( 28604730) Malaria ( 31844061)	Copper levels ( 26025379)
Interacting Genes		70 interacting genes: ALOX15B APC CALR CASP8AP2 CBX4 CDC34 CUL1 CWC25 DAXX DCP2 DMAP1 DZIP3 EHHADH ELAVL1 EXOC8 FADD FBXW11 FHOD1 GABARAP GABARAPL1 GABARAPL2 GMCL1 GRAP HLA-DRB1 IGFN1 IGHG1 IGHV4-31 IKBKB IRF5 IRF8 LNX1 MAP1LC3A MAP1LC3B MAP1LC3C MNAT1 NIF3L1 PFKP RBCK1 RNF111 RO60 SAMHD1 SETD7 SKP2 SQSTM1 TBK1 TCP11L1 TH TNS4 TRIM27 TRIM3 TRIM39 TRIM5 TRIM8 TXN2 UBC UBE2C UBE2D1 UBE2D2 UBE2E1 UBE2H UBE2I UBE2L3 USP15 USP2 USP4 VPS9D1 XAF1 YJU2 YWHAZ ZBTB16	19 interacting genes: ARHGAP32 DPPA4 EPOR FASLG FYN GAB2 KHDRBS1 KIT LAT LCK PLCG1 PRRG4 RAI1 RBPMS REL SHC1 SOS1 TOX TRIM21
Entrez ID		6737	10750
HPRD ID		00170	05062
Ensembl ID		ENSG00000132109	ENSG00000154016
Uniprot IDs		P19474	I3L2P9 Q13588
PDB IDs		2IWG 5JPX 5OLM 6FGA 6S53 7BBD
Enriched GO Terms of Interacting Partners?
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