BRCA1 and TUBB

Number of citations of the paper that reports this interaction (PubMedID 12353262)
27

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vivo)

		BRCA1	TUBB
Description		BRCA1 DNA repair associated	tubulin beta class I
Image
GO Annotations	Cellular Component	Ubiquitin Ligase Complex Lateral Element Gamma-tubulin Large Complex Nucleus Nucleoplasm Chromosome Cytoplasm Plasma Membrane Nuclear Body BRCA1-BARD1 Complex Protein-containing Complex BRCA1-A Complex Ribonucleoprotein Complex	Extracellular Region Nucleus Nuclear Envelope Lumen Cytoplasm Cytosol Cytoskeleton Microtubule Protein-containing Complex Azurophil Granule Lumen Cytoplasmic Ribonucleoprotein Granule Cell Body Membrane Raft Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding DNA Binding Damaged DNA Binding Transcription Coactivator Activity RNA Binding Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Tubulin Binding Enzyme Binding Ubiquitin Protein Ligase Binding RNA Polymerase Binding	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding GTPase Activating Protein Binding MHC Class I Protein Binding Protein-containing Complex Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination Postreplication Repair Double-strand Break Repair Regulation Of Gene Expression By Genetic Imprinting Regulation Of Transcription By RNA Polymerase II Fatty Acid Biosynthetic Process Cellular Response To DNA Damage Stimulus Chromosome Segregation Mitotic G2 DNA Damage Checkpoint Signaling Centrosome Cycle Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Dosage Compensation By Inactivation Of X Chromosome Response To Ionizing Radiation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Gene Expression Protein Ubiquitination Positive Regulation Of Protein Ubiquitination Negative Regulation Of Intracellular Estrogen Receptor Signaling Pathway Positive Regulation Of Histone Acetylation Negative Regulation Of Histone Acetylation Chordate Embryonic Development Response To Estrogen Regulation Of DNA Methylation Negative Regulation Of Fatty Acid Biosynthetic Process Positive Regulation Of DNA Repair Positive Regulation Of Angiogenesis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Centriole Replication Positive Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K4 Methylation Negative Regulation Of Histone H3-K9 Methylation Positive Regulation Of Histone H3-K9 Methylation Regulation Of Cell Cycle Protein Autoubiquitination Positive Regulation Of Histone H4-K20 Methylation Cellular Response To Tumor Necrosis Factor Cellular Response To Indole-3-methanol Protein K6-linked Ubiquitination Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Histone H3-K9 Acetylation Positive Regulation Of Histone H4-K16 Acetylation	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cellular Process Cytoskeleton-dependent Intracellular Transport Natural Killer Cell Mediated Cytotoxicity Regulation Of Synapse Organization Spindle Assembly Cell Division
Pathways		Meiotic synapsis SUMOylation of DNA damage response and repair proteins HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Metalloprotease DUBs Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange TP53 Regulates Transcription of DNA Repair Genes Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Transcriptional Regulation by E2F6 Meiotic recombination Defective DNA double strand break response due to BRCA1 loss of function Defective DNA double strand break response due to BARD1 loss of function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA1 binding function Defective HDR through Homologous Recombination Repair (HRR) due to PALB2 loss of BRCA2/RAD51/RAD51C binding function	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Neutrophil degranulation AURKA Activation by TPX2 Potential therapeutics for SARS
Drugs			Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Patupilone CYT997 CA4P ZEN-012 Tirbanibulin Copper Artenimol Vinflunine Depatuxizumab mafodotin Milataxel Colchiceine
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Gynecologic disease (multivariate analysis) ( 31488892) Menopause (age at onset) ( 26414677 29773799) Monocyte percentage of white cells ( 32888494) Ovarian cancer ( 31488892) Ovarian cancer (MTAG) ( 31488892)	Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Handedness (non-right-handed vs right-handed) ( 31504236) Left-handedness ( 32989287) Leftâ€“right brain asymmetry ( 33723403) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		318 interacting genes: ABL1 ABLIM3 ABRAXAS1 ACACA ACTG1 ACTN3 AHR AKT1 ALDH1A1 ANKRD28 ANTXR1 AP1M1 APLP2 AR ARNT ASH2L ATF1 ATM ATP1B1 ATP1B3 ATR ATRIP AURKA AURKC BABAM1 BAP1 BARD1 BRAP BRAT1 BRCA2 BRCC3 BRIP1 BRSK1 C2CD6 CABYR CASP3 CBX1 CBX5 CCDC120 CCNA1 CCNA2 CCNB1 CCND1 CDC25C CDK1 CDK2 CDK4 CDK7 CDKN2D CEP57L1 CHEK1 CHEK2 CLSPN CNRIP1 CNTLN CNTN4 COL1A1 COMMD1 CREBBP CRY2 CRYZL1 CSNK1D CSNK2A1 CSNK2B CSTF1 CTBP1 CTCFL CTNNB1 CUBN CWF19L2 DALRD3 DBF4 DCLRE1C DCN DDX24 DES DHPS DHX9 DNAJA1 DNAJA3 DNAJB1 DNHD1 DYNC1H1 DYNLT2B E2F1 E2F4 EED EIF3B EIF4A2 EIF5B ELK1 ELK4 ELOA ENO1 EP300 ERCC5 ERO1B ESR1 ETS1 ETV5 EZH2 FAM161A FAM184A FANCA FANCD2 FBXO44 FHL2 FLI1 FLNA FXR2 GCC1 GFI1B GGN GOLGA8DP GTF3C4 GUSBP1 H2AC20 H2AC4 H2AX HDAC1 HDAC2 HECTD3 HGF HIBADH HIVEP1 HNRNPC HNRNPD HORMAD1 HSPA14 HSPA8 HSPD1 IFI16 INPP1 ITIH5 ITPR1 ITPRID2 JAK1 JAK2 JUN JUNB JUND JUP KAT5 KDM1A KIF1B KPNA2 KPNA6 LARP7 LCK LCMT1 LDHC LMNTD1 LMO4 LONRF1 MACROH2A1 MAN2C1 MAP3K1 MAP3K14 MAP3K3 MAP4K4 MARCKSL1 MDC1 MED1 MED21 MID2 MLH1 MNAT1 MSH2 MSH3 MSH6 MT-ND1 MYC MYOZ1 NBN NCOA2 NCOA3 NELFB NFKB1 NFYA NKAPL NMI NPC2 NRIP1 NSD2 NUFIP1 NUP153 OBSCN PARG PEG3 PEX5 PGR PHF12 PIAS1 PIAS4 PIK3R1 PILRB PIN1 PISD POLB POLR2A POLR2H POLR2K POM121 POMGNT1 POU2F1 PPP1CA PPP1CB PPP1R13B PPP2R5C PREP PRKAG3 PRKDC PRMT1 PRPF3 PSAP PSMA6 PSMA7 PSMD9 PSMG1 RACK1 RAD51 RANBP9 RB1 RBBP4 RBBP7 RBBP8 RBL1 RBL2 RCC1L RELA RFC1 RNF216 RPGRIP1 RPL31 RTKN2 RTL10 RUNX1T1 RWDD2B RWDD4 SDK2 SETX SKP2 SMAD2 SMAD3 SMAD4 SMARCA2 SMARCA4 SMC1A SNRNP200 SNX3 SNX6 SOX30 SP1 SPATA4 SQSTM1 SSX2IP STAC2 STAT1 STAT3 STAT5A SUMO1 SYT6 TARS1 TATDN2 TCEA2 TCEANC TEX101 THOC3 TLE4 TMPRSS12 TNS2 TOP1 TOP2A TP53 TP53BP1 TPTE2 TRIM24 TRIM46 TRIM74 TRRAP TSEN54 TSGA10IP TUBA4A TUBB TUBG1 TULP2 TXLNA UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2E2 UBE2E3 UBE2J1 UBE2K UBE2L3 UBE2N UBE2T UBE2W UBE3A UBXN1 USF2 USH2A USP2 VCP WDR6 WNT2B WRN XIAP XRCC1 XRCC5 YY1 ZNF280D ZNF350 ZNF423 ZSCAN21	79 interacting genes: ADAP2 ALDOA APP ARL8B ATXN3 B4GALT1 BMPR2 BRCA1 CDH16 CDKN2A CLIP1 CMTM5 CNN1 CREBBP CRIPT DISC1 DPYSL2 DUX4 DYNLL1 EML4 ESR1 FXR1 GDAP1 GRM1 HDAC6 HGS HTRA2 HTT LINC01554 LNX2 MAGEA2B MAL2 MAP1A MAP3K10 MAP4 MAP6 MAPRE1 MAPT MARK4 MRGBP MTNR1A MX1 NCALD NCAM1 NCAPH2 NDEL1 NPHP1 OGT PFDN4 PLK1 PRKN PTEN RAB8B RACK1 RASSF1 S100A8 S100A9 SDC3 SPP1 STAU1 SUMO2 SYT9 TAOK2 TBCD TGM2 TINF2 TPPP TTBK1 TTK TUBA1A UBE3A VAV1 YWHAB YWHAG YWHAQ YWHAZ ZAP70 ZFYVE21 ZMYND19
Entrez ID		672	203068
HPRD ID		00218	01852
Ensembl ID		ENSG00000012048	ENSG00000196230
Uniprot IDs		A0A024R1V0 P38398	B4DMJ5 B4DQN9 B4DY90 P07437 Q5ST81 Q5SU16
PDB IDs		1JM7 1JNX 1N5O 1OQA 1T15 1T29 1T2U 1T2V 1Y98 2ING 3COJ 3K0H 3K0K 3K15 3K16 3PXA 3PXB 3PXC 3PXD 3PXE 4IFI 4IGK 4JLU 4OFB 4U4A 4Y18 4Y2G 6G2I	3QNZ 3QO0 5N5N 6I2I 6QUS 6QUY 6QVE 6QVJ
Enriched GO Terms of Interacting Partners?
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