TUBB and RACK1

Number of citations of the paper that reports this interaction (PubMedID 12884273)
2

Data Source:
HPRD (in vivo, in vitro)

		TUBB	RACK1
Description		tubulin beta class I	receptor for activated C kinase 1
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nuclear Envelope Lumen Cytoplasm Cytosol Cytoskeleton Microtubule Protein-containing Complex Azurophil Granule Lumen Cytoplasmic Ribonucleoprotein Granule Cell Body Membrane Raft Extracellular Exosome	Phagocytic Cup Nucleus Nucleoplasm Cytoplasm Mitochondrion Cytosol Small Ribosomal Subunit Dendrite Midbody Neuronal Cell Body Perikaryon Perinuclear Region Of Cytoplasm Extracellular Exosome IRE1-RACK1-PP2A Complex
	Molecular Function	GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding GTPase Activating Protein Binding MHC Class I Protein Binding Protein-containing Complex Binding	RNA Binding Protein Kinase C Binding Signaling Receptor Binding Protein Binding Ion Channel Inhibitor Activity Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process Enzyme Binding Protein Phosphatase Binding Protein Tyrosine Kinase Inhibitor Activity Cyclin Binding Receptor Tyrosine Kinase Binding Signaling Adaptor Activity SH2 Domain Binding Protein Homodimerization Activity Ribosome Binding Cadherin Binding BH3 Domain Binding Molecular Adaptor Activity
	Biological Process	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cellular Process Cytoskeleton-dependent Intracellular Transport Natural Killer Cell Mediated Cytotoxicity Regulation Of Synapse Organization Spindle Assembly Cell Division	Positive Regulation Of Protein Phosphorylation Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cell Cycle Gastrulation Negative Regulation Of Gene Expression Protein Ubiquitination Negative Regulation Of Translation Negative Regulation Of Wnt Signaling Pathway Negative Regulation Of Cell Growth Positive Regulation Of Cell Migration Positive Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein Binding Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Localization Negative Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of Golgi To Plasma Membrane Protein Transport Positive Regulation Of Apoptotic Process Pigmentation Positive Regulation Of GTPase Activity Negative Regulation Of Smoothened Signaling Pathway Rhythmic Process Negative Regulation Of Phagocytosis Regulation Of Cell Division Positive Regulation Of Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Cell Cycle Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of Mitochondrial Depolarization Negative Regulation Of Protein Tyrosine Kinase Activity Cellular Response To Glucose Stimulus Cellular Response To Growth Factor Stimulus Rescue Of Stalled Ribosome Negative Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Hydrogen Peroxide-induced Neuron Death Regulation Of Establishment Of Cell Polarity Positive Regulation Of Gastrulation Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Neutrophil degranulation AURKA Activation by TPX2 Potential therapeutics for SARS	Regulation of TNFR1 signaling TNFR1-induced NFkappaB signaling pathway TNFR1-mediated ceramide production
Drugs		Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Patupilone CYT997 CA4P ZEN-012 Tirbanibulin Copper Artenimol Vinflunine Depatuxizumab mafodotin Milataxel Colchiceine	Copper
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Handedness (non-right-handed vs right-handed) ( 31504236) Left-handedness ( 32989287) Leftâ€“right brain asymmetry ( 33723403) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		79 interacting genes: ADAP2 ALDOA APP ARL8B ATXN3 B4GALT1 BMPR2 BRCA1 CDH16 CDKN2A CLIP1 CMTM5 CNN1 CREBBP CRIPT DISC1 DPYSL2 DUX4 DYNLL1 EML4 ESR1 FXR1 GDAP1 GRM1 HDAC6 HGS HTRA2 HTT LINC01554 LNX2 MAGEA2B MAL2 MAP1A MAP3K10 MAP4 MAP6 MAPRE1 MAPT MARK4 MRGBP MTNR1A MX1 NCALD NCAM1 NCAPH2 NDEL1 NPHP1 OGT PFDN4 PLK1 PRKN PTEN RAB8B RACK1 RASSF1 S100A8 S100A9 SDC3 SPP1 STAU1 SUMO2 SYT9 TAOK2 TBCD TGM2 TINF2 TPPP TTBK1 TTK TUBA1A UBE3A VAV1 YWHAB YWHAG YWHAQ YWHAZ ZAP70 ZFYVE21 ZMYND19	112 interacting genes: ACTN2 ADH1B ADRB2 AGTRAP AR ARRDC3 ATG14 ATG5 AURKB BCL2L11 BECN1 BIRC6 BRCA1 BYSL CCNA1 CDKN1A CHERP CNOT2 CRMP1 CSF2RB DDX19B DNM1 DYNLL1 EED EIF6 ELOB EP300 EPOR ESR1 ESS2 FBXW7 FYN GABRB3 GATA4 GGN GNB1 GOLM1 GPBP1 GRAP2 GRIN2B HABP4 HIF1A HNRNPH2 IFNAR1 IFNAR2 IGF1R IK IL2RB IL4R IL7R INSR ITGB1 ITGB2 ITGB5 ITGB7 JAK1 LARP4B LRP12 MAPK6 MCPH1 MKRN2 MTNR1A NFATC1 NR3C1 NSMAF OLA1 PABPC1 PDE4D PIK3R4 PLCG1 PLEC PRKAA1 PRKAB2 PRKCA PRKCB PRKCD PRKCE PRKD1 PRPF31 PTN PTOV1 PTPRM RASA1 RASA3 RB1 RHOA SAT1 SLC27A6 SLC6A3 SLC9A5 SRC SREK1 ST7 STAT1 STAT3 SUMO4 SYT1 TARDBP TBXA2R TENM1 TMEM131 TNFRSF1A TP63 TP73 TSC22D4 TUBB TUBG1 TYK2 USP10 USP54 WDR83 ZSCAN12
Entrez ID		203068	10399
HPRD ID		01852	01503
Ensembl ID		ENSG00000196230	ENSG00000204628
Uniprot IDs		B4DMJ5 B4DQN9 B4DY90 P07437 Q5ST81 Q5SU16	E9KL35 P63244
PDB IDs		3QNZ 3QO0 5N5N 6I2I 6QUS 6QUY 6QVE 6QVJ	4AOW 4UG0 4V6X 5A2Q 5AJ0 5FLX 5LKS 5OA3 5T2C 5VYC 6EK0 6FEC 6G18 6G51 6G53 6G5H 6G5I 6IP5 6IP6 6IP8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6XA1 6Y0G 6Y2L 6Y57 6YBS 6Z6L 6Z6M 6Z6N 6ZLW 6ZM7 6ZME 6ZMI 6ZMO 6ZMT 6ZMW 6ZN5 6ZOJ 6ZOL 6ZON 6ZP4 6ZVH 6ZVJ 6ZXD 6ZXE 6ZXF 6ZXG 6ZXH 7A09 7K5I
Enriched GO Terms of Interacting Partners?
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