SPN and CXCL16

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SPN	CXCL16
Description		sialophorin	C-X-C motif chemokine ligand 16
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Uropod Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Membrane PML Body Extracellular Exosome	Extracellular Region Extracellular Space Plasma Membrane Membrane Integral Component Of Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Hsp70 Protein Binding Heat Shock Protein Binding	Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Chemokine Activity
	Biological Process	T-helper 1 Cell Lineage Commitment Chemotaxis Immune Response Cellular Defense Response Negative Regulation Of Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Regulation Of Immune Response Leukocyte Tethering Or Rolling Regulation Of T Cell Migration Positive Regulation Of T Cell Migration	Receptor-mediated Endocytosis Chemotaxis Signal Transduction T Cell Chemotaxis Positive Regulation Of Cell Growth Positive Regulation Of Cell Migration Response To Cytokine Response To Interferon-gamma Response To Tumor Necrosis Factor
Pathways		Cell surface interactions at the vascular wall Basigin interactions	Chemokine receptors bind chemokines G alpha (i) signalling events
Drugs
Diseases
GWAS			Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058)
Interacting Genes		18 interacting genes: ARL13B CLCA4 CTNNB1 CTSA CXCL16 CYBC1 DAXX ERGIC3 EZR FYN ICAM1 LGALS1 LMNA MSN PLP2 SGTA SIGLEC1 UBQLN2	64 interacting genes: ADAMTSL4 APP AQP2 AQP6 AQP9 ARL13B ATP6V0E1 BIK CARD10 CCDC70 CD53 CERS4 CLDN7 CREB3L1 CXCR6 CYSRT1 FAM209A FFAR2 FKBP7 FNDC9 GJA8 GORAB GPR42 HHATL HOXA1 KASH5 KIR2DL3 KRT31 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-9 KRTAP17-1 KRTAP2-3 KRTAP2-4 KRTAP5-9 LHFPL5 LMNA MDFI MFF MTUS2 MUC1 NBPF19 NEMP1 NOTCH2NLA PEX12 SAR1A SLC16A2 SLC18A1 SLC39A1 SPN SSMEM1 STX1A TAB1 TGM1 TLCD4 TMEM139 TMEM14B TMEM237 TMEM239 TMEM35A TMX2 TSPAN12
Entrez ID		6693	58191
HPRD ID		06770	16103
Ensembl ID		ENSG00000197471	ENSG00000161921
Uniprot IDs		A0A024R629 P16150	Q9H2A7
PDB IDs
Enriched GO Terms of Interacting Partners?
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