SPN and CLCA4

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SPN	CLCA4
Description		sialophorin	chloride channel accessory 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Uropod Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Microvillus External Side Of Plasma Membrane Cell Surface Membrane PML Body Extracellular Exosome	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Apical Plasma Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Hsp70 Protein Binding Heat Shock Protein Binding	Metalloendopeptidase Activity Intracellular Calcium Activated Chloride Channel Activity Chloride Channel Activity Metal Ion Binding
	Biological Process	T-helper 1 Cell Lineage Commitment Chemotaxis Immune Response Cellular Defense Response Negative Regulation Of Cell Adhesion Establishment Or Maintenance Of Cell Polarity Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Regulation Of Immune Response Leukocyte Tethering Or Rolling Regulation Of T Cell Migration Positive Regulation Of T Cell Migration	Proteolysis Chloride Transport Ion Transmembrane Transport
Pathways		Cell surface interactions at the vascular wall Basigin interactions	Stimuli-sensing channels
Drugs
Diseases
GWAS			Fasting glucose ( 34074324)
Interacting Genes		18 interacting genes: ARL13B CLCA4 CTNNB1 CTSA CXCL16 CYBC1 DAXX ERGIC3 EZR FYN ICAM1 LGALS1 LMNA MSN PLP2 SGTA SIGLEC1 UBQLN2	23 interacting genes: AQP2 BDKRB2 ELOVL4 ERGIC3 FAM209A FCER1G FKBP7 GPR42 LMNA MCFD2 MGST3 PANX1 RETREG3 SCN3B SLC22A23 SLC35E2A SLC39A2 SLC39A7 SPN THAP4 TMEM154 TMEM179B TMEM51
Entrez ID		6693	22802
HPRD ID		06770	16719
Ensembl ID		ENSG00000197471	ENSG00000016602
Uniprot IDs		A0A024R629 P16150	Q14CN2
PDB IDs
Enriched GO Terms of Interacting Partners?
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