TMEM108 and ARHGEF6

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		TMEM108	ARHGEF6
Description		transmembrane protein 108	Rac/Cdc42 guanine nucleotide exchange factor 6
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Early Endosome Endosome Membrane Postsynaptic Density Integral Component Of Membrane Axon Dendrite Somatodendritic Compartment Axon Cytoplasm	Cytosol Lamellipodium
	Molecular Function	Molecular_function Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Receptor-mediated Endocytosis Retrograde Axonal Transport Biological_process Dentate Gyrus Development Neuron Projection Development Positive Regulation Of Neurotrophin TRK Receptor Signaling Pathway Postsynaptic Density Organization Dendrite Extension Modulation Of Excitatory Postsynaptic Potential Cellular Response To Brain-derived Neurotrophic Factor Stimulus	Apoptotic Process JNK Cascade Lamellipodium Assembly Regulation Of Catalytic Activity
Pathways			NRAGE signals death through JNK G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle
Drugs
Diseases
GWAS		Bipolar disorder ( 33263727) Chronotype ( 30696823) Daytime nap ( 33568662) IgE grass sensitization ( 22036096) Iron status biomarkers (total iron binding capacity) ( 28334935) Menarche (age at onset) ( 27182965 21102462) Parkinson's disease progression (cognitive) ( 33958783) Stroke ( 32693751) Systolic blood pressure ( 30224653 30578418) Waist circumference ( 28552196)	Breast cancer ( 29059683)
Interacting Genes		7 interacting genes: ANXA7 ARHGEF6 FHL3 FKBP7 NOTCH3 SGTB SH3GL2	38 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CBFA2T3 CCDC33 CDC42 CDK6 EPHB2 GIT1 GIT2 GOLGA2 GPRASP2 HSF2BP KRT27 NUTM1 PAK1 PAK2 PAK3 PARVB PNMA1 POU6F2 RWDD2A SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 TP53BP2 TRAF2 TRIM54 YWHAG ZNF580
Entrez ID		66000	9459
HPRD ID		11329	02226
Ensembl ID		ENSG00000144868	ENSG00000129675
Uniprot IDs		B3KT64 Q6UXF1	B7Z3C7 Q15052 Q8N4Q3
PDB IDs			1UJY 1WYR
Enriched GO Terms of Interacting Partners?
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