ARHGEF6 and ARAP3

Number of citations of the paper that reports this interaction (PubMedID 17314030)
16

Data Source:
BioGRID (two hybrid)

		ARHGEF6	ARAP3
Description		Rac/Cdc42 guanine nucleotide exchange factor 6	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
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GO Annotations	Cellular Component	Cytosol Lamellipodium	Ruffle Cytoplasm Cytoskeleton Plasma Membrane Lamellipodium
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Metal Ion Binding
	Biological Process	Apoptotic Process JNK Cascade Lamellipodium Assembly Regulation Of Catalytic Activity	Cytoskeleton Organization Signal Transduction Vesicle-mediated Transport Positive Regulation Of GTPase Activity
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Regulation of cytoskeletal remodeling and cell spreading by IPP complex components G beta:gamma signalling through CDC42 CDC42 GTPase cycle RAC1 GTPase cycle RHOU GTPase cycle	RHOA GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS		Breast cancer ( 29059683)	Cerebral amyloid deposition (PET imaging) ( 26252872) Diffuse large B cell lymphoma ( 25261932) Fasting plasma glucose ( 32682390) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Household income ( 31844048) Lung cancer ( 28604730) Mean arterial pressure ( 27618448) Offspring birth weight ( 31043758)
Interacting Genes		38 interacting genes: ADAM15 ARAP3 ARHGEF7 BMPR1B CAPNS1 CBFA2T3 CCDC33 CDC42 CDK6 EPHB2 GIT1 GIT2 GOLGA2 GPRASP2 HSF2BP KRT27 NUTM1 PAK1 PAK2 PAK3 PARVB PNMA1 POU6F2 RWDD2A SH2D1A SH3GL3 SIRPA SMAD1 SMAD2 SMAD3 TGFBR1 TGFBR2 TMEM108 TP53BP2 TRAF2 TRIM54 YWHAG ZNF580	10 interacting genes: ANKS1A ARHGEF6 CD2AP CLNK GGA3 INPPL1 PARD6B SAMHD1 SH3KBP1 TNKS2
Entrez ID		9459	64411
HPRD ID		02226	09441
Ensembl ID		ENSG00000129675	ENSG00000120318
Uniprot IDs		B7Z3C7 Q15052 Q8N4Q3	Q05CH1 Q8WWN8 Q9H7C1
PDB IDs		1UJY 1WYR	2KG5 2LNW 5JCP 5JD0 7A9B
Enriched GO Terms of Interacting Partners?
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