BMX and PTPN21

Number of citations of the paper that reports this interaction (PubMedID 11013262)
11

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		BMX	PTPN21
Description		BMX non-receptor tyrosine kinase	protein tyrosine phosphatase non-receptor type 21
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane Ruffle Membrane	Cytoplasm Cytoskeleton
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding	Protein Tyrosine Phosphatase Activity Protein Binding
	Biological Process	Adaptive Immune Response Protein Phosphorylation Phosphatidylinositol Biosynthetic Process Apoptotic Process Cell Adhesion Signal Transduction Mesoderm Development Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Protein Autophosphorylation B Cell Receptor Signaling Pathway	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation
Pathways		Apoptotic cleavage of cellular proteins Synthesis of PIPs at the plasma membrane
Drugs		Fostamatinib Zanubrutinib
Diseases
GWAS			Prudent dietary pattern ( 28644415) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		26 interacting genes: APP BCAR1 BIRC2 BTK CASP3 CAV1 CLNK EGFR ERBB2 FBXO25 ITK KDR NOPCHAP1 PAK1 PTK2 PTPN21 PTPRD RAP1A RUFY1 RUFY2 SRC STAT1 STAT3 STAT5A TEC TNFRSF1B	28 interacting genes: AKAP1 BAG3 BMX CATSPER1 CWC22 ERBB4 FAM214B FBXO17 GOLGA2 KIF1C MAGOHB MOB3C NEK6 NSMF PAK5 PARD6A PIBF1 QARS1 RASD1 SNX18 SRC TEC TRIM14 TTC8 UBASH3B VPS26C YAP1 ZNF497
Entrez ID		660	11099
HPRD ID		02111	04468
Ensembl ID		ENSG00000102010	ENSG00000070778
Uniprot IDs		P51813	Q16825
PDB IDs		2EKX 2YS2 3SXR 3SXS 6I99
Enriched GO Terms of Interacting Partners?
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