PTPN21 and BMX

Number of citations of the paper that reports this interaction (PubMedID 11013262)
11

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		PTPN21	BMX
Description		protein tyrosine phosphatase non-receptor type 21	BMX non-receptor tyrosine kinase
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton	Nucleoplasm Cytosol Plasma Membrane Ruffle Membrane
	Molecular Function	Protein Tyrosine Phosphatase Activity Protein Binding	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Metal Ion Binding
	Biological Process	Protein Dephosphorylation Peptidyl-tyrosine Dephosphorylation	Adaptive Immune Response Protein Phosphorylation Phosphatidylinositol Biosynthetic Process Apoptotic Process Cell Adhesion Signal Transduction Mesoderm Development Intracellular Signal Transduction Peptidyl-tyrosine Autophosphorylation Protein Autophosphorylation B Cell Receptor Signaling Pathway
Pathways			Apoptotic cleavage of cellular proteins Synthesis of PIPs at the plasma membrane
Drugs			Fostamatinib Zanubrutinib
Diseases
GWAS		Prudent dietary pattern ( 28644415) Suicidality in mood disorders ( 33783297) Suicide attempt severity in mood disorders ( 33783297)
Interacting Genes		28 interacting genes: AKAP1 BAG3 BMX CATSPER1 CWC22 ERBB4 FAM214B FBXO17 GOLGA2 KIF1C MAGOHB MOB3C NEK6 NSMF PAK5 PARD6A PIBF1 QARS1 RASD1 SNX18 SRC TEC TRIM14 TTC8 UBASH3B VPS26C YAP1 ZNF497	26 interacting genes: APP BCAR1 BIRC2 BTK CASP3 CAV1 CLNK EGFR ERBB2 FBXO25 ITK KDR NOPCHAP1 PAK1 PTK2 PTPN21 PTPRD RAP1A RUFY1 RUFY2 SRC STAT1 STAT3 STAT5A TEC TNFRSF1B
Entrez ID		11099	660
HPRD ID		04468	02111
Ensembl ID		ENSG00000070778	ENSG00000102010
Uniprot IDs		Q16825	P51813
PDB IDs			2EKX 2YS2 3SXR 3SXS 6I99
Enriched GO Terms of Interacting Partners?
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