BMPR2 and CASP10

		BMPR2	CASP10
Description		bone morphogenetic protein receptor type 2	caspase 10
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Caveola Clathrin-coated Pit Adherens Junction Basal Plasma Membrane Cell Surface Postsynaptic Density Apical Plasma Membrane Dendrite Neuronal Cell Body Receptor Complex Spanning Component Of Plasma Membrane	Cytoplasm Cytosol CD95 Death-inducing Signaling Complex Ripoptosome
	Molecular Function	Protein Serine/threonine Kinase Activity Transforming Growth Factor Beta-activated Receptor Activity Protein Binding ATP Binding Activin Receptor Activity, Type II Phosphatase Activator Activity Growth Factor Binding Signaling Receptor Activator Activity BMP Binding Protein Serine/threonine Kinase Activator Activity Cadherin Binding Metal Ion Binding BMP Receptor Activity Transcription Regulator Activator Activity Protein Tyrosine Kinase Binding	Cysteine-type Endopeptidase Activity Protein Binding Ubiquitin Protein Ligase Binding Death Effector Domain Binding Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
	Biological Process	Blood Vessel Development Osteoblast Differentiation Mesoderm Formation Maternal Placenta Development Endothelial Cell Proliferation Positive Regulation Of Endothelial Cell Proliferation Lymphangiogenesis Blood Vessel Remodeling Chondrocyte Development Negative Regulation Of Systemic Arterial Blood Pressure Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Aortic Valve Development Pulmonary Valve Development Atrioventricular Valve Morphogenesis Mitral Valve Morphogenesis Tricuspid Valve Morphogenesis Endocardial Cushion Development Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Protein Phosphorylation Transmembrane Receptor Protein Serine/threonine Kinase Signaling Pathway Brain Development Cellular Response To Starvation Anterior/posterior Pattern Specification Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Epithelial Cell Migration Positive Regulation Of Pathway-restricted SMAD Protein Phosphorylation Regulation Of Lung Blood Pressure Proteoglycan Biosynthetic Process Negative Regulation Of Cell Growth Positive Regulation Of Bone Mineralization BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Activin Receptor Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Ossification Negative Regulation Of Vasoconstriction Positive Regulation Of Transcription By RNA Polymerase II Lung Alveolus Development Negative Regulation Of Smooth Muscle Cell Proliferation Cardiac Muscle Tissue Development Positive Regulation Of Axon Extension Involved In Axon Guidance Negative Regulation Of Muscle Cell Differentiation Limb Development Endochondral Bone Morphogenesis Positive Regulation Of SMAD Protein Signal Transduction Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Lymphatic Endothelial Cell Differentiation Artery Development Venous Blood Vessel Development Positive Regulation Of Cartilage Development Retina Vasculature Development In Camera-type Eye Pharyngeal Arch Artery Morphogenesis Cellular Response To Growth Factor Stimulus Cellular Response To BMP Stimulus Positive Regulation Of Protein Serine/threonine Kinase Activity Endothelial Cell Apoptotic Process Negative Regulation Of Chondrocyte Proliferation Semi-lunar Valve Development Negative Regulation Of DNA Biosynthetic Process	Proteolysis Apoptotic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Apoptotic Signaling Pathway Execution Phase Of Apoptosis
Pathways		Signaling by BMP	TP53 Regulates Transcription of Caspase Activators and Caspases FasL/ CD95L signaling TRAIL signaling NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
Drugs		Dibotermin alfa Fostamatinib
Diseases
GWAS		High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence (MTAG) ( 29326435) Mean corpuscular hemoglobin ( 32888494) Medication use (HMG CoA reductase inhibitors) ( 31015401) PR interval ( 32439900) Reticulocyte fraction of red cells ( 32888494) Triglyceride levels ( 32203549 32154731) Urate levels ( 23263486)	Alanine aminotransferase levels ( 33547301) Basal cell carcinoma ( 25855136) Chronic lymphocytic leukemia ( 28165464 23770605) Chronic lymphocytic leukemia or rheumatoid arthritis ( 31407831) Mean corpuscular hemoglobin ( 32888494)
Interacting Genes		59 interacting genes: ACTR8 ACVR1 ACVR1B ARSA BMP10 BMP2 BMP4 BMP6 BMP7 BMPR1A BMPR1B C4BPA CASP10 CASP8 CCDC89 CES1 CHRND CRYAB CTBP1 DYNLT1 ERBB4 FHL2 FOXL1 FRS3 GDF2 GDF5 GDF6 GDF9 HAT1 HNRNPR IGFBP2 INHBB LIMK1 LMX1A LSM10 LSP1 MAP3K8 MAPK8 MERTK MOS NBEA NOP56 PDZRN3 PMPCA PPP1CC PRKCB RAB11FIP1 RABGGTA SMURF1 SULT1E1 TDGF1 TGFBR1 TOPBP1 TRIB3 TRPC1 TSR1 TUBB TUBB4A TWF1	36 interacting genes: BFAR BID BMPR2 CASP1 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP8AP2 CASP9 CCAR1 CFLAR DEDD DEDD2 DSP ECE2 ERBB4 FADD IGFBP2 NFKBIL1 NPTX1 OIP5 PHF20L1 POLR2A PRDX6 RB1 RIOK3 RYBP SCARB1 TNFRSF1A TRAF1 XIAP YBX3
Entrez ID		659	843
HPRD ID		02880	03458
Ensembl ID		ENSG00000204217	ENSG00000003400
Uniprot IDs		Q13873	A0A0S2Z3G5 A0A0S2Z3Z5 Q92851
PDB IDs		2HLQ 3G2F
Enriched GO Terms of Interacting Partners?
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