ILRUN and FBXO25

Number of citations of the paper that reports this interaction (PubMedID 23940030)
8

Data Source:
BioGRID (enzymatic study)

		ILRUN	FBXO25
Description		inflammation and lipid regulator with UBA-like and NBR1-like domains	F-box protein 25
Image			No pdb structure
GO Annotations	Cellular Component	Phagophore Assembly Site Nucleus Cytoplasm Centrosome Cytosol Nuclear Speck	Ubiquitin Ligase Complex Nucleus Nucleolus Cytoplasm SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Ubiquitin Binding	Actin Binding Ubiquitin-protein Transferase Activity
	Biological Process	Macroautophagy Negative Regulation Of Type I Interferon Production Negative Regulation Of Tumor Necrosis Factor Production Negative Regulation Of DNA Binding Innate Immune Response Negative Regulation Of Defense Response To Virus Negative Regulation Of Protein Localization To Nucleus	Protein Ubiquitination
Pathways
Drugs
Diseases
GWAS		Liver enzyme levels (gamma-glutamyl transferase) ( 33972514)	Neonatal cytokine/chemokine levels (fetal genetic effect) ( 30134952) Nontraumatic osteonecrosis of the femoral head ( 32701715)
Interacting Genes		5 interacting genes: APP FBXO25 MAP3K1 RPSA SMURF1	83 interacting genes: ANKRD13A APLF AXL BMX BRME1 C7orf50 CDK5RAP2 CDK9 CENPB CUL1 CXXC4 DAXX DCX DDX42 DEPTOR DNAJB2 DNAJC8 DYRK3 DYRK4 EGFR EID3 EIF4E2 ELK1 EPN1 FKBP3 G3BP1 GRK2 GTF2B GTF2IRD2 HIP1 HMCES HP1BP3 IL21 ILRUN ING3 IRS1 JHY KDR KRT8 LMCD1 LUC7L MAT2B NKX2-5 NSRP1 NUAK1 ODF2 ORC4 PADI4 PAK4 PCK1 PDGFRA PIP4K2C PPID PPP1R8 PRKCA PRKG2 PRR15 PRRG1 PSMD4 RABEP2 RBM8A RHBDD1 RIOK3 RPAP3 RPS10 RPS6KB2 SAMHD1 SERBP1 SKP1 STAC SYTL2 TBX5 TCEAL2 TCEANC TCP10L TMA7 TNIP2 TRUB1 TWF1 UBE2D3 UBQLN1 UBQLN2 WDSUB1
Entrez ID		64771	26260
HPRD ID		12837	16439
Ensembl ID		ENSG00000196821	ENSG00000147364
Uniprot IDs		A0A024RCW2 Q9H6K1	A0A024QZ88 Q8TCJ0
PDB IDs		6VHI
Enriched GO Terms of Interacting Partners?
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