SHBG and EIF3E

Number of citations of the paper that reports this interaction (PubMedID 15862967)
3

Data Source:
BioGRID (two hybrid)

		SHBG	EIF3E
Description		sex hormone binding globulin	eukaryotic translation initiation factor 3 subunit E
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 3 Complex Membrane Eukaryotic 43S Preinitiation Complex PML Body Eukaryotic 48S Preinitiation Complex Extracellular Exosome Eukaryotic Translation Initiation Factor 3 Complex, EIF3e
	Molecular Function	Steroid Binding Androgen Binding Protein Binding	RNA Binding Translation Initiation Factor Activity Protein Binding Cadherin Binding Protein N-terminus Binding
	Biological Process		Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Formation Of Cytoplasmic Translation Initiation Complex Translational Initiation Regulation Of Translational Initiation Positive Regulation Of Translation Negative Regulation Of Translational Initiation Positive Regulation Of MRNA Binding
Pathways			L13a-mediated translational silencing of Ceruloplasmin expression Translation initiation complex formation Formation of a pool of free 40S subunits Formation of the ternary complex, and subsequently, the 43S complex Ribosomal scanning and start codon recognition GTP hydrolysis and joining of the 60S ribosomal subunit
Drugs		Masoprocol Diethylstilbestrol Levonorgestrel Progesterone Spironolactone Toremifene Estrone Tamoxifen Clomifene Dienestrol Hesperetin Zinc Genistein Naringenin Quercetin 4'-Hydroxyflavanone Afimoxifene Estriol Phenolphthalein Norethynodrel Dioxybenzone Zeranol Gestrinone Equol Zinc acetate Zinc chloride Zinc sulfate, unspecified form Estriol tripropionate
Diseases
GWAS		Androgen levels ( 22936694) Body shape index ( 34021172) Body size at age 10 ( 32376654) Brain morphology (MOSTest) ( 32665545) Estradiol levels ( 34255042) Glycated hemoglobin levels ( 34059833) Heel bone mineral density ( 30598549) Hormone measurements ( 24049095) Medication use (calcium channel blockers) ( 31015401) Protein quantitative trait loci ( 18464913) Red cell distribution width ( 27863252) Refractive error ( 32231278) Sex hormone levels ( 26014426) Sex hormone-binding globulin levels ( 22675492 22829776) Testosterone levels ( 21998597) Uterine fibroids ( 31649266) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Brain morphology (MOSTest) ( 32665545) Coffee consumption ( 31046077) Dupuytren's disease ( 28886342 21732829) Heel bone mineral density ( 30598549) Macular thickness ( 30535121) Male-pattern baldness ( 28196072) Ossification of the posterior longitudinal ligament of the spine ( 25064007)
Interacting Genes		62 interacting genes: A2M ACP3 ACTA2 ACTB ACTG2 AK2 AKR1B1 AP1B1 AP2A1 APEH APOBEC3C APOD ASB16-AS1 ATP5F1A AZGP1 C9orf24 CD177 CEP192 CLDN4 CLEC4G COL1A2 CTSD DDX3Y DES DSTN EEF1A1 EIF3E EIF3F FLNA FLOT1 FYTTD1 GRB2 HDHD5 HYI JMJD7-PLA2G4B KLK4 MPDU1 MT1F MT1G MT2A MXD4 NOMO1 PACSIN2 PKM PLA2G4A PLP2 PSTPIP1 PSTPIP2 PTGDS RMND5B SEMA3F SLC37A1 SLC37A4 SNAPIN SNRNP70 SORD SRF SRI TINAGL1 UBE2O UBE3A ZC3H12A	34 interacting genes: ATM C4orf19 COPS6 COPS7A COPS7B COPS8 DDX24 DRC3 EIF3C EIF3L EIF4ENIF1 EPAS1 EPN2 GPAA1 GPBP1L1 HAP1 IFIT1 ISCA2 KPRP LINC01554 MAPK1IP1L MIIP MRNIP NDRG1 NSF OGT PRRC2A RUNDC3A SHBG SMAD9 TRIM27 TRIM55 TRIM63 ZNF48
Entrez ID		6462	3646
HPRD ID		01646	03734
Ensembl ID		ENSG00000129214	ENSG00000104408
Uniprot IDs		B0FWH2 B0FWH8 B4DYU0 I3L145 P04278	P60228
PDB IDs		1D2S 1F5F 1KDK 1KDM 1LHN 1LHO 1LHU 1LHV 1LHW 6PYA 6PYB 6PYF 6ULB	3J8B 3J8C 6FEC 6YBD 6ZMW 6ZON 6ZP4 6ZVJ 7A09
Enriched GO Terms of Interacting Partners?
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