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SDC4 and MDK
Number of citations of the paper that reports this interaction (PubMedID
8621465
)
21
Data Source:
HPRD
(in vitro)
SDC4
MDK
Description
syndecan 4
midkine
Image
GO Annotations
Cellular Component
Golgi Lumen
Plasma Membrane
Integral Component Of Plasma Membrane
Focal Adhesion
Cell Surface
Costamere
Lysosomal Lumen
Membrane Raft
Extracellular Exosome
Extracellular Region
Cytoplasm
Cell Projection
Collagen-containing Extracellular Matrix
Molecular Function
Fibronectin Binding
Protein Kinase C Binding
Protein Binding
Identical Protein Binding
Thrombospondin Receptor Activity
Protein Binding
Growth Factor Activity
Heparin Binding
Chondroitin Sulfate Binding
Heparan Sulfate Binding
Biological Process
Ureteric Bud Development
Neural Tube Closure
Regulation Of Fibroblast Migration
Cell Migration
Wound Healing
Negative Regulation Of T Cell Proliferation
Positive Regulation Of Protein Kinase Activity
Positive Regulation Of Stress Fiber Assembly
Positive Regulation Of Focal Adhesion Assembly
Inner Ear Receptor Cell Stereocilium Organization
Positive Regulation Of Exosomal Secretion
Positive Regulation Of Extracellular Exosome Assembly
Behavioral Fear Response
Leukocyte Chemotaxis Involved In Inflammatory Response
T Cell Activation Involved In Immune Response
Positive Regulation Of Leukocyte Chemotaxis
Cytoskeleton Organization
Negative Regulation Of Cell Adhesion
Signal Transduction
Nervous System Development
Short-term Memory
Response To Xenobiotic Stimulus
Response To Wounding
Negative Regulation Of Cardiac Muscle Cell Apoptotic Process
Positive Regulation Of Epithelial To Mesenchymal Transition
Positive Regulation Of Macrophage Chemotaxis
Positive Regulation Of Keratinocyte Proliferation
Positive Regulation Of Neuron Projection Development
Response To Auditory Stimulus
Dentate Gyrus Development
Cerebellar Granular Layer Development
Cerebral Cortex Development
Cell Differentiation
Negative Regulation Of Ossification
Adrenal Gland Development
Positive Regulation Of Cell Migration
Defecation
Regulation Of Chondrocyte Differentiation
Positive Regulation Of Interleukin-12 Production
Tissue Regeneration
Negative Regulation Of Neuron Apoptotic Process
Estrous Cycle
Positive Regulation Of T Cell Differentiation
Negative Regulation Of Regulatory T Cell Differentiation
Positive Regulation Of Cell Adhesion
Positive Regulation Of Transcription, DNA-templated
Regulation Of Bone Remodeling
Oogenesis
Positive Regulation Of Oligodendrocyte Differentiation
Positive Regulation Of Inflammatory Response
Regulation Of Behavior
Response To Glucocorticoid
Positive Regulation Of Cell Division
Positive Regulation Of Cartilage Development
Positive Regulation Of Smooth Muscle Cell Chemotaxis
Positive Regulation Of Neutrophil Chemotaxis
Negative Regulation Of Canonical Wnt Signaling Pathway
Negative Regulation Of Inflammatory Response To Wounding
Positive Regulation Of Inflammatory Response To Wounding
Glial Cell Projection Elongation
Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Positive Regulation Of Leukocyte Cell-cell Adhesion
Negative Regulation Of Epithelial Cell Apoptotic Process
Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell
Positive Regulation Of Blood Vessel Branching
Positive Regulation Of Vascular Endothelial Cell Proliferation
Positive Regulation Of Artery Morphogenesis
Positive Regulation Of Neural Precursor Cell Proliferation
Regulation Of Actin Cytoskeleton Reorganization
Positive Regulation Of Hepatocyte Proliferation
Positive Regulation Of Neutrophil Extravasation
Positive Regulation Of Neuron Migration
Pathways
A tetrasaccharide linker sequence is required for GAG synthesis
HS-GAG biosynthesis
HS-GAG biosynthesis
HS-GAG degradation
Cell surface interactions at the vascular wall
Syndecan interactions
Syndecan interactions
Defective B4GALT7 causes EDS, progeroid type
Defective B3GAT3 causes JDSSDHD
Defective EXT2 causes exostoses 2
Defective EXT1 causes exostoses 1, TRPS2 and CHDS
Defective B3GALT6 causes EDSP2 and SEMDJL1
Retinoid metabolism and transport
Signaling by ALK
Signaling by ALK
NOTCH2 Activation and Transmission of Signal to the Nucleus
Drugs
Diseases
GWAS
Malaria (
31844061
)
Psoriasis (
20953189
)
Alzheimer's disease or fasting glucose levels (pleiotropy) (
30805717
)
Autism spectrum disorder or schizophrenia (
28540026
)
Feeling miserable (
29500382
)
Immunoglobulin A (
20694011
)
Schizophrenia (
28991256
29483656
30285260
)
Interacting Genes
20 interacting genes:
CASK
CCL5
CXCR4
EP300
GIPC1
IL7R
MAL
MDK
PMP22
PRKCA
PRKCD
PTEN
PXN
SDCBP
SGTA
SGTB
TANK
TGFB1I1
TGFB3
UBC
32 interacting genes:
ALK
AP1M1
CDC42
FBXO7
HCK
JAK1
JAK2
JOSD2
LRP1
LRP2
LRP6
LRP8
MAPK6
MIEF2
NCL
NFU1
PBX3
PTPRZ1
RBFA
RPL18A
SDC1
SDC3
SDC4
SRPK2
STAT1
TCEA2
TGM1
TMED8
TSPAN1
UBQLN1
UBQLN2
UBQLN4
Entrez ID
6385
4192
HPRD ID
08366
01200
Ensembl ID
ENSG00000124145
ENSG00000110492
Uniprot IDs
B4E1S6
P31431
P21741
PDB IDs
1EJP
1EJQ
1OBY
1YBO
1MKC
1MKN
Enriched GO Terms of Interacting Partners
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