SDC4 and IL7R

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		SDC4	IL7R
Description		syndecan 4	interleukin 7 receptor
Image
GO Annotations	Cellular Component	Golgi Lumen Plasma Membrane Integral Component Of Plasma Membrane Focal Adhesion Cell Surface Costamere Lysosomal Lumen Membrane Raft Extracellular Exosome	Extracellular Region Nucleoplasm Cytosol Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Clathrin-coated Endocytic Vesicle Membrane
	Molecular Function	Fibronectin Binding Protein Kinase C Binding Protein Binding Identical Protein Binding Thrombospondin Receptor Activity	Antigen Binding Cytokine Receptor Activity Interleukin-7 Receptor Activity Protein Binding
	Biological Process	Ureteric Bud Development Neural Tube Closure Regulation Of Fibroblast Migration Cell Migration Wound Healing Negative Regulation Of T Cell Proliferation Positive Regulation Of Protein Kinase Activity Positive Regulation Of Stress Fiber Assembly Positive Regulation Of Focal Adhesion Assembly Inner Ear Receptor Cell Stereocilium Organization Positive Regulation Of Exosomal Secretion Positive Regulation Of Extracellular Exosome Assembly	Regulation Of DNA Recombination Cell Morphogenesis Negative Regulation Of T Cell Mediated Cytotoxicity Immune Response Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Population Proliferation Regulation Of Cell Size Positive Regulation Of Gene Expression T Cell Differentiation Positive Regulation Of T Cell Differentiation In Thymus Interleukin-7-mediated Signaling Pathway B Cell Proliferation Lymph Node Development Homeostasis Of Number Of Cells Defense Response To Gram-positive Bacterium Negative Regulation Of T Cell Apoptotic Process Positive Regulation Of Receptor Signaling Pathway Via STAT
Pathways		A tetrasaccharide linker sequence is required for GAG synthesis HS-GAG biosynthesis HS-GAG biosynthesis HS-GAG degradation Cell surface interactions at the vascular wall Syndecan interactions Syndecan interactions Defective B4GALT7 causes EDS, progeroid type Defective B3GAT3 causes JDSSDHD Defective EXT2 causes exostoses 2 Defective EXT1 causes exostoses 1, TRPS2 and CHDS Defective B3GALT6 causes EDSP2 and SEMDJL1 Retinoid metabolism and transport	Interleukin-7 signaling Interleukin-7 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Malaria ( 31844061) Psoriasis ( 20953189)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Allergic rhinitis ( 30013184 31361310) Ankylosing spondylitis ( 23749187) Asthma ( 31361310 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Basophil percentage of white cells ( 32888494) Blood protein levels ( 30072576 29875488 28240269) Eczema ( 31361310) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Medication use (adrenergics, inhalants) ( 31015401) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244 21244703 24076602 19525953 21833088) Neutrophil percentage of white cells ( 32888494 27863252) Primary biliary cholangitis ( 23000144 21399635 26394269 28062665 30643196) Primary biliary cirrhosis ( 22961000) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 25751624 17554260) Ulcerative colitis ( 21297633) White blood cell count ( 32888494)
Interacting Genes		20 interacting genes: CASK CCL5 CXCR4 EP300 GIPC1 IL7R MAL MDK PMP22 PRKCA PRKCD PTEN PXN SDCBP SGTA SGTB TANK TGFB1I1 TGFB3 UBC	110 interacting genes: AGTRAP ALYREF APOL3 CIRBP CPSF1 CRLF2 DDX21 DDX39B DDX3X DDX5 DHX36 DHX9 EIF2AK2 ELAVL1 EMG1 FAU FUS FYN G3BP1 H1-10 H1-2 H1-4 H2BC21 HNRNPA0 HNRNPA3 HNRNPAB HNRNPC HNRNPD HNRNPDL HNRNPH3 HNRNPL HNRNPR HNRNPU HNRNPUL1 HNRNPUL2 IL2RG IL7 ILF2 ILF3 JAK1 JAK3 KIT LYN MALL MAP4 MS4A1 NCL NONO PABPC1 PABPC4 PABPN1 PIK3R1 PTBP1 PTK2B PTMA PURA PURB QKI RACK1 RAD21 RBM3 RBMX RPL15 RPL18 RPL22 RPL29 RPL30 RPL31 RPL6 RPL7 RPL8 RPS20 RPS3 RPSA RRAGA RSL1D1 SAFB SDC4 SF1 SF3A1 SF3B1 SNRNP70 SNRPA SNRPB SNRPD1 SNRPD2 SNRPD3 SNRPE SNRPF SNRPG SRP14 SRP9 SRSF3 SRSF9 SSB STAT3 STAT5A STAT5B SYNCRIP TMEM120B TOE1 TOP1 TSLP U2AF1 U2AF2 YBX1 YBX3 YWHAE YWHAG ZNF787
Entrez ID		6385	3575
HPRD ID		08366	00893
Ensembl ID		ENSG00000124145	ENSG00000168685
Uniprot IDs		B4E1S6 P31431	P16871
PDB IDs		1EJP 1EJQ 1OBY 1YBO	3DI2 3DI3 3UP1 5J11 6P50 6P67
Enriched GO Terms of Interacting Partners?
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