BIK and ADGRE2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		BIK	ADGRE2
Description		BCL2 interacting killer	adhesion G protein-coupled receptor E2
Image
GO Annotations	Cellular Component	Endomembrane System Integral Component Of Membrane Mitochondrial Membrane	Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Leading Edge Membrane Ruffle Membrane
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity Calcium Ion Binding Protein Binding Chondroitin Sulfate Binding
	Biological Process	Apoptotic Process Male Gonad Development Apoptotic Mitochondrial Changes Positive Regulation Of Protein-containing Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Release Of Cytochrome C From Mitochondria	Inflammatory Response Cell Adhesion Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Cell Migration Regulation Of Mast Cell Degranulation Granulocyte Chemotaxis
Pathways			Class B/2 (Secretin family receptors)
Drugs
Diseases
GWAS		Prostate cancer ( 25939597 21743057) Prostate cancer (SNP x SNP interaction) ( 22219177)	Blood protein levels ( 30072576) Plasma androstenedione levels in resected early stage-receptor positive breast cancer ( 28429243)
Interacting Genes		94 interacting genes: ADGRE2 ADIPOQ AIG1 ALG8 ANKRD46 APOD APP ASB11 BCL2 BCL2A1 BCL2L1 BCL2L10 BCL2L2 BMP10 BNIP3 BRICD5 BTN2A2 C14orf180 C3orf52 C4orf3 CD53 CD72 CLDN19 CMTM5 CMTM7 CNIH1 CNIH3 CREB3 CRKL CTXN3 CXCL16 CYB561 CYB5B ELOVL4 ERGIC3 EXOC3L2 FAM209A FAM241B FAM3C FATE1 FCGR1A GPX8 GRM2 INSIG2 KCNN4 MARCHF5 MCL1 MS4A13 NAT8 NR2F2 NRM PBX3 PGAP2 PGRMC1 PLN PLP1 PLP2 PLPP4 REEP4 RUSF1 S100A1 SCAMP4 SEC22A SELENOK SERP1 SERP2 SLC35E3 SLC37A4 SLC39A7 SMIM1 SOCS3 STRIT1 STX8 TANK TMBIM1 TMEM107 TMEM11 TMEM14B TMEM14C TMEM199 TMEM222 TMEM229B TMEM243 TMEM254 TMEM60 TMEM80 TMEM86B TMEM97 TRARG1 TSPO2 UBIAD1 VAMP3 VAMP5 ZFPL1	19 interacting genes: AQP6 BIK CCDC107 CREB3L1 ELOVL4 ELOVL7 FAM209A FCER1G HSD17B13 KIR2DL3 LMNA MARCHF6 MFSD5 MMGT1 MTERF3 SAR1A SLC7A14 TLCD4 TMEM80
Entrez ID		638	30817
HPRD ID		04547	07308
Ensembl ID		ENSG00000100290	ENSG00000127507
Uniprot IDs		A0A024R4X6 Q13323	A0JNV7 Q9UHX3
PDB IDs		2IPE	2BO2 2BOU 2BOX
Enriched GO Terms of Interacting Partners?
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