CCL13 and XCL1

Number of citations of the paper that reports this interaction (PubMedID 28381538)
37

Data Source:
BioGRID (pull down)

		CCL13	XCL1
Description		C-C motif chemokine ligand 13	X-C motif chemokine ligand 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space
	Molecular Function	Signaling Receptor Binding Protein Binding Chemokine Activity CCR Chemokine Receptor Binding	Protein Binding Chemokine Activity Chemokine Receptor Binding Protein Homodimerization Activity CCR Chemokine Receptor Binding
	Biological Process	Monocyte Chemotaxis Cellular Calcium Ion Homeostasis Chemotaxis Inflammatory Response Cytoskeleton Organization Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Regulation Of Cell Shape Neutrophil Chemotaxis Killing Of Cells Of Other Organism Positive Regulation Of GTPase Activity Eosinophil Chemotaxis Lymphocyte Chemotaxis Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor	Positive Regulation Of T Cell Mediated Cytotoxicity Monocyte Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of T Cell Cytokine Production Positive Regulation Of T Cell Cytokine Production Negative Regulation Of T-helper 1 Type Immune Response Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Positive Regulation Of T Cell Chemotaxis Neutrophil Chemotaxis Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-10 Production Mature Natural Killer Cell Chemotaxis Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of GTPase Activity Negative Regulation Of Transcription, DNA-templated Lymphocyte Chemotaxis Regulation Of Inflammatory Response Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-4 Cellular Response To Tumor Necrosis Factor Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Granzyme B Production Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Thymocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of B Cell Chemotaxis Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	Chemokine receptors bind chemokines G alpha (q) signalling events
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Crohn's disease ( 22412388) Inflammatory bowel disease ( 23128233) Metabolite levels ( 23823483)	Blood protein levels ( 30072576 29875488) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Metabolite levels ( 23823483)
Interacting Genes		28 interacting genes: ACKR2 ACKR4 APAF1 APP CCL11 CCL2 CCL21 CCL24 CCL26 CCL28 CCL5 CCL8 CCR1 CCR3 CCR5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL9 HNRNPH3 MMP1 MMP3 NOD2 PF4 PPBP XCL1	21 interacting genes: CCL11 CCL13 CCL21 CCL24 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL9 FBLN5 KRTAP10-3 PF4 PF4V1 TNFSF18 VCAN XCR1
Entrez ID		6357	6375
HPRD ID		03230	02595
Ensembl ID		ENSG00000181374	ENSG00000143184
Uniprot IDs		Q99616	P47992
PDB IDs		2RA4	1J8I 1J9O 2HDM 2JP1 2N54 2NYZ
Enriched GO Terms of Interacting Partners?
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