XCL1 and FBLN5

		XCL1	FBLN5
Description		X-C motif chemokine ligand 1	fibulin 5
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix Extracellular Exosome Elastic Fiber
	Molecular Function	Protein Binding Chemokine Activity Chemokine Receptor Binding Protein Homodimerization Activity CCR Chemokine Receptor Binding	Integrin Binding Calcium Ion Binding Protein Binding Protein C-terminus Binding Extracellular Matrix Constituent Conferring Elasticity Protein Homodimerization Activity
	Biological Process	Positive Regulation Of T Cell Mediated Cytotoxicity Monocyte Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Negative Regulation Of T Cell Cytokine Production Positive Regulation Of T Cell Cytokine Production Negative Regulation Of T-helper 1 Type Immune Response Inflammatory Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Response To Virus Positive Regulation Of T Cell Chemotaxis Neutrophil Chemotaxis Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-2 Production Positive Regulation Of Interleukin-10 Production Mature Natural Killer Cell Chemotaxis Negative Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of GTPase Activity Negative Regulation Of Transcription, DNA-templated Lymphocyte Chemotaxis Regulation Of Inflammatory Response Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Chemokine-mediated Signaling Pathway Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Interferon-gamma Cellular Response To Interleukin-1 Cellular Response To Interleukin-4 Cellular Response To Tumor Necrosis Factor Cellular Response To Transforming Growth Factor Beta Stimulus Positive Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Granzyme B Production Positive Regulation Of Neutrophil Chemotaxis Positive Regulation Of Thymocyte Migration Positive Regulation Of Natural Killer Cell Chemotaxis Positive Regulation Of Granzyme A Production Negative Regulation Of T-helper 1 Cell Activation Positive Regulation Of B Cell Chemotaxis Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of T-helper 1 Cell Cytokine Production Positive Regulation Of Immunoglobulin Production In Mucosal Tissue Negative Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of CD8-positive, Alpha-beta T Cell Proliferation	Regulation Of Cell Growth Cell-matrix Adhesion Protein Localization To Cell Surface Secretion Elastic Fiber Assembly Regulation Of Removal Of Superoxide Radicals
Pathways		Chemokine receptors bind chemokines G alpha (q) signalling events	Elastic fibre formation Molecules associated with elastic fibres Molecules associated with elastic fibres
Drugs
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Metabolite levels ( 23823483)	Diastolic blood pressure ( 30578418) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol levels x thiazide or thiazide-like diuretics use interaction ( 31806883) Heel bone mineral density ( 30598549) Height ( 25429064 31562340 18391951) Hip circumference adjusted for BMI ( 34021172) Major depressive disorder ( 34099189) Major depressive disorder x sex interaction ( 34099189) Optic disc size ( 31809533) Pulse pressure ( 27841878 30578418) Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		21 interacting genes: CCL11 CCL13 CCL21 CCL24 CCL26 CCL28 CCL5 CXCL10 CXCL11 CXCL12 CXCL14 CXCL17 CXCL2 CXCL9 FBLN5 KRTAP10-3 PF4 PF4V1 TNFSF18 VCAN XCR1	23 interacting genes: ATN1 GFI1B GSC HOXA1 LGMN LOXL1 LPA MEOX2 NDUFA4 NUFIP2 OTX1 PAXIP1 PDIA3 PPP2R5C PRNP PSMC1 SERPINA1 SERPINA5 SOD3 ST3GAL3 TOP3B TRIP13 XCL1
Entrez ID		6375	10516
HPRD ID		02595	05204
Ensembl ID		ENSG00000143184	ENSG00000140092
Uniprot IDs		P47992	A0A024R6G3 Q9UBX5
PDB IDs		1J8I 1J9O 2HDM 2JP1 2N54 2NYZ
Enriched GO Terms of Interacting Partners?
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