SCN2A and RNF130

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		SCN2A	RNF130
Description		sodium voltage-gated channel alpha subunit 2	ring finger protein 130
Image			No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Membrane T-tubule Axon Intrinsic Component Of Plasma Membrane Node Of Ranvier Paranode Region Of Axon Sodium Channel Complex Glutamatergic Synapse Integral Component Of Presynaptic Membrane	Cytoplasm Integral Component Of Membrane
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding	Ubiquitin-protein Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Sodium Ion Transport Nervous System Development Memory Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuron Apoptotic Process Cellular Response To Hypoxia Membrane Depolarization During Action Potential	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Programmed Cell Death Protein Ubiquitination
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	Antigen processing: Ubiquitination & Proteasome degradation
Drugs		Tramadol Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Propofol Cocaine Zonisamide Promethazine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Metergoline Bioallethrin Amylmetacresol Fish oil
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Bipolar disorder ( 33263727 31043756) Diastolic blood pressure ( 30224653) Epilepsy ( 30531953) Factor VII activity ( 30642921) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Febrile seizures (MMR vaccine-unrelated) ( 25344690) Focal epilepsy ( 30531953) Generalized epilepsy ( 30531953) Periodontitis (DPAL) ( 24024966) Refractive error ( 32231278) Trunk fat mass ( 28552196) Urinary sodium excretion ( 31409800)	LDL cholesterol ( 21347282) Pre-treatment viral load in HIV-1 infection ( 31219150) Systolic blood pressure ( 30224653)
Interacting Genes		10 interacting genes: ANK3 ARHGEF10L B4GAT1 BAZ2B GALNT13 MPP3 PKP4 PLA2R1 RNF130 SCN4B	13 interacting genes: ARPC4 FGFR3 SCN2A TGFBR1 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E3 UBE2N UBE2Z
Entrez ID		6326	55819
HPRD ID		03133	11504
Ensembl ID		ENSG00000136531	ENSG00000113269
Uniprot IDs		Q99250	E5RI87 Q2HIY3 Q86XS8
PDB IDs		2KAV 4JPZ 4RLY 6BUT 6J8E
Enriched GO Terms of Interacting Partners?
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