SCN2A and ARHGEF10L

Number of citations of the paper that reports this interaction (PubMedID 16169070)
888

Data Source:
HPRD (two hybrid)

		SCN2A	ARHGEF10L
Description		sodium voltage-gated channel alpha subunit 2	Rho guanine nucleotide exchange factor 10 like
Image			No pdb structure
GO Annotations	Cellular Component	Voltage-gated Sodium Channel Complex Plasma Membrane Integral Component Of Plasma Membrane Intercalated Disc Membrane T-tubule Axon Intrinsic Component Of Plasma Membrane Node Of Ranvier Paranode Region Of Axon Sodium Channel Complex Glutamatergic Synapse Integral Component Of Presynaptic Membrane	Cytosol
	Molecular Function	Voltage-gated Ion Channel Activity Voltage-gated Sodium Channel Activity Protein Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity
	Biological Process	Sodium Ion Transport Nervous System Development Memory Intrinsic Apoptotic Signaling Pathway In Response To Osmotic Stress Neuronal Action Potential Regulation Of Ion Transmembrane Transport Sodium Ion Transmembrane Transport Myelination Neuron Apoptotic Process Cellular Response To Hypoxia Membrane Depolarization During Action Potential	Actin Cytoskeleton Organization SREBP Signaling Pathway Regulation Of Catalytic Activity Regulation Of Small GTPase Mediated Signal Transduction Positive Regulation Of Stress Fiber Assembly
Pathways		Interaction between L1 and Ankyrins Phase 0 - rapid depolarisation	NRAGE signals death through JNK G alpha (12/13) signalling events RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs		Tramadol Ranolazine Phenytoin Topiramate Valproic acid Lamotrigine Carbamazepine Oxcarbazepine Propofol Cocaine Zonisamide Promethazine Tetrodotoxin Brivaracetam Tetracaine Amylocaine Propoxycaine Pramocaine Pentoxyverine Dichlorobenzyl alcohol Metergoline Bioallethrin Amylmetacresol Fish oil
Diseases
GWAS		Adult body size ( 32376654) Age at first birth ( 34211149) Age at first sexual intercourse ( 34211149) Bipolar disorder ( 33263727 31043756) Diastolic blood pressure ( 30224653) Epilepsy ( 30531953) Factor VII activity ( 30642921) Febrile seizures ( 25344690) Febrile seizures (MMR vaccine-related) ( 25344690) Febrile seizures (MMR vaccine-unrelated) ( 25344690) Focal epilepsy ( 30531953) Generalized epilepsy ( 30531953) Periodontitis (DPAL) ( 24024966) Refractive error ( 32231278) Trunk fat mass ( 28552196) Urinary sodium excretion ( 31409800)	Basal cell carcinoma ( 18849993) Initial pursuit acceleration in psychotic disorders ( 29064472) Insomnia ( 27992416) Major depressive disorder x sex interaction ( 34099189) Obesity-related traits ( 23251661) Response to hepatitis C treatment ( 22095909)
Interacting Genes		10 interacting genes: ANK3 ARHGEF10L B4GAT1 BAZ2B GALNT13 MPP3 PKP4 PLA2R1 RNF130 SCN4B	4 interacting genes: ANXA9 DRAP1 NR4A1 SCN2A
Entrez ID		6326	55160
HPRD ID		03133	07679
Ensembl ID		ENSG00000136531	ENSG00000074964
Uniprot IDs		Q99250	B4DTL3 Q5VXI4 Q9HCE6
PDB IDs		2KAV 4JPZ 4RLY 6BUT 6J8E
Enriched GO Terms of Interacting Partners?
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