ATXN7 and LAMB2

Number of citations of the paper that reports this interaction (PubMedID 21078624)
26

Data Source:
BioGRID (two hybrid)

		ATXN7	LAMB2
Description		ataxin 7	laminin subunit beta 2
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytosol Microtubule Cytoskeleton Nuclear Matrix	Extracellular Region Basement Membrane Laminin-3 Complex Endoplasmic Reticulum Lumen Neuromuscular Junction Synaptic Cleft Laminin Complex Laminin-11 Complex Collagen-containing Extracellular Matrix Extracellular Exosome
	Molecular Function	Protein Binding	Integrin Binding Structural Molecule Activity Extracellular Matrix Structural Constituent Protein Binding
	Biological Process	Microtubule Cytoskeleton Organization Nucleus Organization Negative Regulation Of Microtubule Depolymerization Visual Perception Histone Deubiquitination	Axon Guidance Neuromuscular Junction Development Visual Perception Animal Organ Morphogenesis Tissue Development Astrocyte Development Schwann Cell Development Cell Migration Substrate Adhesion-dependent Cell Spreading Axon Extension Involved In Regeneration Retina Development In Camera-type Eye Basement Membrane Assembly Metanephric Glomerular Visceral Epithelial Cell Development Metanephric Glomerular Basement Membrane Development
Pathways		HATs acetylate histones Ub-specific processing proteases	Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) MET activates PTK2 signaling Post-translational protein phosphorylation
Drugs
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cataracts ( 34127677) Cortical surface area (MOSTest) ( 32665545) Diastolic blood pressure ( 30224653) Estimated glomerular filtration rate ( 31152163) Red cell distribution width ( 32888494) Refractive error ( 32231278) Schizophrenia ( 28991256 25056061 29483656) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Type 2 diabetes ( 30054458)	Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Mood instability ( 31168069) Myocardial infarction ( 33532862) PR interval ( 32439900) Resting heart rate ( 27798624) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		65 interacting genes: ACTN1 ACTN2 ACTN4 ADAM33 AGRN CARD10 CEP70 CEP72 COG6 CPOX CRIM1 CRX EFEMP1 EFEMP2 FBN1 FN1 GNAT1 GOLGA2 GOLGA3 GPRASP1 GRN IMPDH2 ITPRID2 JAG2 KALRN KAT2A LAMB1 LAMB2 LRSAM1 LTBP4 MATN2 MEGF6 MPRIP NELL1 NELL2 NOC2L NUP62 PDHB PICK1 PNMA1 PPP1R12C PSMC1 RABEP1 RAD23A RNF31 SERINC3 SIAH1 SNX1 SPRY1 SUMO1 SUMO2 SYNJ2 TAF10 THY1 TP53BP2 TRAF2 TRIM23 TRIM27 TRIM54 TRRAP TXNDC11 UBQLN2 USP22 VCP VWF	12 interacting genes: ATXN7 CIP2A CTNNB1 HOXA1 KPNA2 ORC5 PIK3R2 PLEKHA5 RBL1 STAT3 TSR2 ZNF512B
Entrez ID		6314	3913
HPRD ID		06365	01034
Ensembl ID		ENSG00000163635	ENSG00000172037
Uniprot IDs		O15265 Q9UPD8	P55268
PDB IDs		2KKR
Enriched GO Terms of Interacting Partners?
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