RPS6KA2 and OTUD4

		RPS6KA2	OTUD4
Description		ribosomal protein S6 kinase A2	OTU deubiquitinase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol Synapse Meiotic Spindle	Nucleus Cytosol
	Molecular Function	Magnesium Ion Binding Protein Serine/threonine Kinase Activity Ribosomal Protein S6 Kinase Activity Protein Serine/threonine/tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity	RNA Binding Thiol-dependent Deubiquitinase Protein Binding Molecular Adaptor Activity Lys63-specific Deubiquitinase Activity
	Biological Process	Oocyte Maturation Brain Renin-angiotensin System Signal Transduction Chemical Synaptic Transmission Heart Development Negative Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Cardiac Muscle Cell Apoptotic Process Peptidyl-serine Phosphorylation Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Negative Regulation Of Cell Cycle Negative Regulation Of Meiotic Nuclear Division Heart Contraction Regulation Of Protein Processing Cellular Response To Carbohydrate Stimulus	Protein Deubiquitination Negative Regulation Of Toll-like Receptor Signaling Pathway Innate Immune Response Protein K63-linked Deubiquitination Protein K48-linked Deubiquitination Positive Regulation Of DNA Demethylation Regulation Of Protein K48-linked Deubiquitination Negative Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways		ERK/MAPK targets CREB phosphorylation Senescence-Associated Secretory Phenotype (SASP) Senescence-Associated Secretory Phenotype (SASP) Recycling pathway of L1 CREB1 phosphorylation through NMDA receptor-mediated activation of RAS signaling RSK activation RSK activation Gastrin-CREB signalling pathway via PKC and MAPK
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Alzheimer's disease progression score ( 29860282) Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756) Blood pressure (smoking interaction) ( 25189868) CafÃ©-au-lait macule number in neurofibromatosis type1 ( 32869517) Dental caries ( 23259602) HDL cholesterol levels in HIV infection ( 33109212) Inflammatory bowel disease ( 27569725 23128233) Macrovascular complications in type 2 diabetes ( 33430853) Pre-treatment viral load in HIV-1 infection ( 31219150) Smooth-surface caries ( 24556642) Urinary metabolite levels in chronic kidney disease ( 31959995) Waist circumference ( 28552196)	Angiotensin-converting enzyme inhibitor intolerance ( 28030426) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Heel bone mineral density ( 30598549 28869591) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172 25673412) Lung function (FEV1) ( 30061609) Malaria ( 31844061) Mean corpuscular hemoglobin concentration ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 31628463) Red blood cell count ( 32888494) Refractive error ( 32231278) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 27863252) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		19 interacting genes: AFDN BAD CREB1 DYNLT1 DYNLT2 FLNC FOS JUN KCNJ6 L1CAM MAGI1 MAP2K1 MAPK1 MAPK3 OTUD4 SHANK1 TBXT THBS2 TP53	13 interacting genes: ALKBH3 DNAAF5 EXOSC8 MAVS REL RPS6KA2 STAT1 TCF4 TEC UBC USP7 VDR ZNF655
Entrez ID		6196	54726
HPRD ID		03403	11033
Ensembl ID		ENSG00000071242	ENSG00000164164
Uniprot IDs		B7Z3B5 Q15349 X5D337	Q01804
PDB IDs
Enriched GO Terms of Interacting Partners?
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