RNF4 and BCL2L1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		RNF4	BCL2L1
Description		ring finger protein 4	BCL2 like 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Nuclear Body PML Body Microtubule End	Cytoplasm Mitochondrion Mitochondrial Outer Membrane Mitochondrial Inner Membrane Mitochondrial Matrix Endoplasmic Reticulum Centrosome Cytosol Integral Component Of Membrane Synaptic Vesicle Membrane Nuclear Membrane Bcl-2 Family Protein Complex
	Molecular Function	DNA Binding Ubiquitin-protein Transferase Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Nuclear Receptor Coactivator Activity Nucleosome Binding SUMO Polymer Binding Identical Protein Binding	Protein Binding Protein Kinase Binding Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity BH3 Domain Binding
	Biological Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Response To Arsenic-containing Substance Protein Autoubiquitination Protein K63-linked Ubiquitination Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein K6-linked Ubiquitination Regulation Of Spindle Assembly Regulation Of Kinetochore Assembly	Ovarian Follicle Development In Utero Embryonic Development Release Of Cytochrome C From Mitochondria Endocytosis Germ Cell Development Spermatogenesis Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Male Gonad Development Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Apoptotic Mitochondrial Changes Fertilization Suppression By Virus Of Host Apoptotic Process Regulation Of Cytokinesis Response To Cytokine Regulation Of Growth Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Response To Cycloheximide Regulation Of Mitochondrial Membrane Permeability Neuron Apoptotic Process Defense Response To Virus Regulation Of Mitochondrial Membrane Potential Mitochondrion Morphogenesis Cellular Response To Amino Acid Stimulus Cellular Response To Alkaloid Cellular Response To Gamma Radiation Apoptotic Process In Bone Marrow Cell Negative Regulation Of Release Of Cytochrome C From Mitochondria Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Hepatocyte Apoptotic Process Negative Regulation Of Execution Phase Of Apoptosis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Processing of DNA double-strand break ends Antigen processing: Ubiquitination & Proteasome degradation	BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome RAS processing STAT5 activation downstream of FLT3 ITD mutants
Drugs			4'-FLUORO-1,1'-BIPHENYL-4-CARBOXYLIC ACID Isosorbide Gossypol
Diseases
GWAS		Colorectal adenoma (advanced) ( 29228715) Colorectal cancer ( 29228715) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Dimensional psychopathology (Social) ( 29496196) Tourette syndrome ( 30818990)	Brain morphology (MOSTest) ( 32665545) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Oppositional defiant disorder dimensions in attention-deficit hyperactivity disorder ( 26184070) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Prudent dietary pattern ( 28644415) Putamen volume ( 29147026) Subcortical brain region volumes ( 25607358)
Interacting Genes		133 interacting genes: AIM2 AKAP17A AR ARID3C ATF2 ATXN1 BCL2L1 BTBD1 BTBD3 C14orf119 C18orf25 CAMK2B CAMK2D CCL2 CFL2 CREB1 DAXX DDX39A DDX39B DES DESI1 EHHADH EIF2A ESR1 ESRRA FADD FAM118A FAM9A FKBP6 GMCL1 GSC2 H3C14 HGS HMGA1 HNF4A HNRNPCL1 HNRNPCL2 HNRNPH1 HNRNPK IKBKG IKZF1 IMPDH1 KLHL12 LCE1B LCE1D LCE1E LCE1F LCE2B LCE2C LCE2D LCE3B LCE5A LXN MYD88 NKX3-1 NMNAT1 NTAQ1 NVL PAICS PATZ1 PCBP3 PGR PHC1 PROP1 PRR20A PRR20B PRR20C PRR20D PRR20E RHOXF2 RUNX1T1 SCML2 SEPTIN3 SKIL SNAPC5 SOX5 SP1 SRPK2 SSNA1 STX1A STX2 STX4 SUMO1 SUMO2 TBP TCF20 TERF2 TFG THAP1 TOP2B TRAF2 TRAF3 TRAF4 TRAF5 TRAIP TRIM28 TRIM38 TRIM54 TRIP13 TRPS1 UBC UBE2A UBE2B UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2H UBE2I UBE2K UBE2L6 UBE2N UBE2T UBE2W UBQLN1 UBQLN2 UBTD2 UEVLD VENTX ZBTB26 ZBTB34 ZBTB6 ZC3H10 ZCCHC17 ZFP42 ZNF275 ZNF319 ZNF696 ZNF792 ZNRD2	111 interacting genes: ACTB AKT1 ANTXR1 APAF1 AURKA AVEN BAD BAG1 BAK1 BAX BBC3 BCAP31 BCL2 BCL2L10 BCL2L11 BCL2L12 BCL2L14 BCLAF1 BECN1 BID BIK BLK BMF BNIP1 BNIP3 BNIP3L BNIP5 BNIPL C10orf67 CAPN1 CASP1 CASP8 CASP9 CDKN2A CFLAR CHEK1 CREB3 CRYAA CRYAB CYCS DOCK7 EDRF1 ELOVL4 ERGIC3 FBP1 FKBP8 G0S2 GLOD4 GNLY GOLM1 GORAB GSK3A GSK3B HNRNPA1 HRK IKZF3 IRS1 IRS2 LARP1 MAPK14 MAPK8 MAPK9 MAPKAPK2 MCL1 METTL23 MOAP1 MTIF3 MTNR1B MTOR NLRP1 PARK7 PDIA4 PINK1 PLD3 PLK1 PLK3 PMAIP1 PPHLN1 PPP1CA PRKN PSEN1 PSEN2 PTN RAD9A RAF1 RBM5 REEP4 RHBDD2 RIC3 RNF183 RNF4 RTN1 RTN4 RYR3 SIVA1 SNCA SPNS1 TLE1 TMBIM6 TMEM50B TP53 TP53BP2 TPT1 UBE2I UBR1 UHRF2 VAC14 VDAC1 ZFYVE1 ZHX1 ZNF219
Entrez ID		6047	598
HPRD ID		04167	02497
Ensembl ID		ENSG00000063978	ENSG00000171552
Uniprot IDs		P78317	A0A0S2Z3C5 Q07817 Q5TE63
PDB IDs		2EA6 2XEU 4PPE	1BXL 1G5J 1LXL 1MAZ 1R2D 1R2E 1R2G 1R2H 1R2I 1YSG 1YSI 1YSN 2B48 2LP8 2LPC 2M03 2M04 2ME8 2ME9 2MEJ 2O1Y 2O2M 2O2N 2P1L 2PON 2YJ1 2YQ6 2YQ7 2YXJ 3CVA 3FDL 3FDM 3INQ 3IO8 3PL7 3QKD 3R85 3SP7 3SPF 3WIZ 3ZK6 3ZLN 3ZLO 3ZLR 4A1U 4A1W 4AQ3 4BPK 4C52 4C5D 4CIN 4EHR 4HNJ 4IEH 4PPI 4QVE 4QVF 4QVX 4TUH 4Z9V 5AGW 5AGX 5B1Z 5C3G 5FMJ 5FMK 5VAY 5VX3 6BF2 6DCN 6DCO 6F46 6HJL 6IJQ 6O0K 6O0L 6O0M 6O0O 6O0P 6RNU 6ST2 6VWC 6X7I 6ZHC 7CA4 7JGV 7JGW
Enriched GO Terms of Interacting Partners?
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